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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorFrank, Derk
dc.contributor.authorKennon, Simon
dc.contributor.authorBonaros, Nikolaos
dc.contributor.authorRomano, Mauro
dc.contributor.authorLefèvre, Thierry
dc.contributor.authorDi Mario, Carlo
dc.contributor.authorGarcía del Blanco, Bruno
dc.date.accessioned2019-08-22T06:18:04Z
dc.date.available2019-08-22T06:18:04Z
dc.date.issued2019-05-21
dc.identifier.citationFrank D, Kennon S, Bonaros N, Romano M, Lefèvre T, Di Mario C, et al. Trial protocol for the validation of the ‘ Toronto Aortic Stenosis Quality of Life (TASQ) Questionnaire’ in patients undergoing surgical aortic valve replacement (SAVR) or transfemoral (TF) transcatheter aortic valve implantation (TAVI): the TASQ registry. Open Heart. 2019;6(1):e001008.
dc.identifier.issn2053-3624
dc.identifier.urihttp://hdl.handle.net/11351/4268
dc.descriptionAortic stenosis; Aortic valve replacement; Quality of life
dc.description.abstractPatients with severe aortic stenosis (AS) have a reduced life expectancy and quality of life (QoL), owing to advanced age and the presence of multiple comorbidities. Currently, there is no AS-specific QoL measurement tool, which prevents an accurate assessment of how this chronic condition and its treatment affect patients. The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) was developed in order to address this deficiency. METHODS: The present trial protocol was designed to enable validation of the TASQ, which has been produced in five languages (English, French, German, Italian and Spanish) to increase usability. Patients with severe AS who are undergoing surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) will be asked to complete the TASQ and, for comparative purposes, the Kansas City Cardiomyopathy Questionnaire and the general health-related QoL Short Form-12 questionnaire. The questionnaires will be completed prior to the intervention, at discharge, as well as at 30 days and 3 months follow-up. A total of 290 patients will be recruited across one Canadian and nine European centres. Overall, the protocol validation aims to include 120 patients undergoing transfemoral TAVI (TF-TAVI), 120 undergoing SAVR and up to 50 being treated medically. The primary objective of the registry is to validate the TASQ in five different languages. The secondary objective is to assess the utility of the TASQ for assessing differences in QoL outcome between patients undergoing TF-TAVI, SAVR or medical management for their AS. DISCUSSION: Validation and roll-out of the TASQ will enable clinicians to capture an accurate assessment of how AS and its management affects the QoL of patients and will help them to determine the most appropriate treatment strategy for individual patients.
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofseriesOpen Heart;6(1)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectVàlvula aòrtica - Cirurgia
dc.subjectQualitat de vida - Avaluació
dc.subjectAssaigs clínics
dc.subject.meshTranscatheter Aortic Valve Replacement
dc.subject.meshQuality of Life
dc.subject.meshClinical Trial Protocols as Topic
dc.titleTrial protocol for the validation of the 'Toronto Aortic Stenosis Quality of Life (TASQ) Questionnaire' in patients undergoing surgical aortic valve replacement (SAVR) or transfemoral (TF) transcatheter aortic valve implantation (TAVI): the TASQ registry
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1136/openhrt-2019-001008
dc.subject.decssustitución valvular aórtica con catéter
dc.subject.decscalidad de vida
dc.subject.decsprotocolos de ensayos clínicos como asunto
dc.relation.publishversionhttps://openheart.bmj.com/content/6/1/e001008.full
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Frank D] Departmentof Internal Medicine III (Cardiology, Angiology and Intensive Care Medicine), UKSH University Clinical Center Schleswig-Holstein, Kiel, Germany. DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Kiel, Germany. [Kennon S] Department of Cardiology, Barts Heart Centre, St. Bartholomew's Hospital London, London, UK. [Bonaros N] Departmentof Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria. [Romano M, Lefèvre T] Departmentof Thoracic and Cardiovascular Surgery, Department of Interventional Cardiology, Hopital Privé Jacques Cartier, Massy, France. [Di Mario C] Department of Structural Interventional Cardiology, Department of Cardiac Surgery, Careggi University Hospital, Florence, Italy. [Garcia B] Servei de Cardiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
dc.identifier.pmid31218003
dc.identifier.wosWOS:000471922200065
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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