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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorParra-Robert, Marina
dc.contributor.authorCasals, Eudald
dc.contributor.authorMassana Martinell, Nuria
dc.contributor.authorZeng, Muling
dc.contributor.authorPerramón, Meritxell
dc.contributor.authorFernández-Varo, Guillermo
dc.contributor.authorFranco Puntes, Victor
dc.date.accessioned2020-03-10T12:49:28Z
dc.date.available2020-03-10T12:49:28Z
dc.date.issued2019-08-29
dc.identifier.citationParra-Robert M, Casals E, Massana N, Zeng M, Perramón M, Fernández-Varo G, et al. Beyond the scavenging of reactive oxygen species (ROS): direct effect of cerium oxide nanoparticles in reducing fatty acids content in an in vitro model of hepatocellular steatosis. Biomolecules. 2019 Aug 29;9(9):e425.
dc.identifier.issn2218-273X
dc.identifier.urihttp://hdl.handle.net/11351/4721
dc.descriptionCerium oxide nanoparticles; Oxidative stress; Nonalcoholic fatty liver disease
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is characterized by hepatic accumulation of lipids. Antisteatotic effects of cerium oxide nanoparticles (CeO2NPs) have recently been shown in animal models of liver disease. However, it is unclear whether the activity of CeO2NPs is related solely to the decrease in oxidative stress or, in addition, they directly decrease liver fatty acid accumulation. To address this question, in this work, we used an in vitro model of hepatocellular steatosis, exposing HepG2 cells to oleic and palmitic acid. Cell uptake of CeO2NPs and their effect on oxidative stress and viability of hepatic cells cultured with H2O2 were also evaluated. Results show that CeO2NPs were uptaken by HepG2 cells and reduced oxidative stress and improved cell viability. Treatment with oleic and palmitic acid increased lipogenesis and the content of different fatty acids. CeO2NPs reduced palmitic and stearic acid and most fatty acids consisting of more than 18 carbon atoms. These effects were associated with significant changes in elongase and desaturase activity. In conclusion, CeO2NPs directly protected HepG2 cells from cell injury in oxidative stress conditions and reduced fatty acid content in steatotic conditions by inducing specific changes in fatty acid metabolism, thus showing potential in the treatment of NAFLD.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesBiomolecules;9(9)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectNanopartícules
dc.subjectEstrès oxidatiu
dc.subjectEsteatosi hepàtica
dc.subject.meshMetal Nanoparticles
dc.subject.meshOxidative Stress
dc.subject.meshNon-alcoholic Fatty Liver Disease
dc.titleBeyond the scavenging of reactive oxygen species (ROS): direct efect of cerium oxide nanoparticles in reducing fatty acids content in an in vitro model of hepatocellular steatosis
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/biom9090425
dc.subject.decsnanopartículas metálicas
dc.subject.decsestrés oxidativo
dc.subject.decsesteatosis hepática no alcohólica
dc.relation.publishversionhttps://www.mdpi.com/2218-273X/9/9/425
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Parra-Robert M, Massana N, Perramón M] Service of Biochemistry and Molecular Genetics, Hospital Clinic Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain. [Casals E, Zeng M] School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China. [Fernández-Varo G] Service of Biochemistry and Molecular Genetics, Hospital Clinic Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain. Departament of Biomedicine, University of Barcelona, Barcelona, Spain. [Puntes V] Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC, The Barcelona Institute of Science and Technology (BIST), Universitat Autònoma de Barcelona, Bellaterra, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
dc.identifier.pmid31470518
dc.identifier.wos000489102800037
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI15-00077
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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