Show simple item record

 
dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorMartín-Gonzalo, Juan-Andrés
dc.contributor.authorPulido-Valdeolivas, Irene
dc.contributor.authorWang, Yu
dc.contributor.authorWang, Ting
dc.contributor.authorChiclana-Actis, Guadalupe
dc.contributor.authorAlgarra-Lucas, Maria del Carmen
dc.contributor.authorGómez Andrés, David
dc.date.accessioned2020-09-07T09:35:04Z
dc.date.available2020-09-07T09:35:04Z
dc.date.issued2019-09-06
dc.identifier.citationMartín-Gonzalo JA, Pulido-Valdeolivas I, Wang Y, Wang T, Chiclana-Actis G, Algarra-Lucas MC, et al. Permutation entropy and irreversibility in gait kinematic time series from patients with mild cognitive decline and early Alzheimer’s dementia. Entropy. 2019 Sep 6;21(9):868.
dc.identifier.issn1099-4300
dc.identifier.urihttp://hdl.handle.net/11351/5212
dc.descriptionPermutation entropy; Irreversibility; Mild cognitive impairment
dc.description.abstractGait is a basic cognitive purposeful action that has been shown to be altered in late stages of neurodegenerative dementias. Nevertheless, alterations are less clear in mild forms of dementia, and the potential use of gait analysis as a biomarker of initial cognitive decline has hitherto mostly been neglected. Herein, we report the results of a study of gait kinematic time series for two groups of patients (mild cognitive impairment and mild Alzheimer’s disease) and a group of matched control subjects. Two metrics based on permutation patterns are considered, respectively measuring the complexity and irreversibility of the time series. Results indicate that kinematic disorganisation is present in early phases of cognitive impairment; in addition, they depict a rich scenario, in which some joint movements display an increased complexity and irreversibility, while others a marked decrease. Beyond their potential use as biomarkers, complexity and irreversibility metrics can open a new door to the understanding of the role of the nervous system in gait, as well as its adaptation and compensatory mechanisms.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesEntropy;21(9)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectDisfunció cerebral mínima
dc.subjectTrastorns de la marxa
dc.subjectSistema nerviós - Degeneració
dc.subject.meshCognitive Dysfunction
dc.subject.meshGait Analysis
dc.subject.meshNeurodegenerative Diseases
dc.titlePermutation entropy and irreversibility in gait kinematic time series from patients with mild cognitive decline and early Alzheimer’s dementia
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/e21090868
dc.subject.decsdisfunción cognitiva
dc.subject.decsanálisis de la marcha
dc.subject.decsenfermedades neurodegenerativas
dc.relation.publishversionhttps://www.mdpi.com/1099-4300/21/9/868
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Martín-Gonzalo JA] Escuela de Fisioterapia de la ONCE, Universidad Autónoma de Madrid, Madrid, Spain. Departamento de Anatomía, Histología y Neurociencia, Universidad Autónoma de Madrid, Madrid, Spain. [Pulido-Valdeolivas I] Departamento de Anatomía, Histología y Neurociencia, Universidad Autónoma de Madrid, Madrid, Spain. Visual Pathway Laboratory, Neuroimmunology Center and Neurology Department, Biomedical Research, Center August Pi i Sunyer (IDIBAPS), Hospital Clínic Barcelona, Barcelona, Spain. [Wang Y, Wang T] Departamento de Anatomía, Histología y Neurociencia, Universidad Autónoma de Madrid, Madrid, Spain. [Chiclana-Actis G, Algarra-Lucas MC] Unidad de Trastornos Cognitivos, Servicio de Neurología, Hospital Universitario Infanta Sofía, Madrid, Spain. [Gómez-Andrés D] Departamento de Anatomía, Histología y Neurociencia, Universidad Autónoma de Madrid, Madrid, Spain. Servei de Pediatria General i Especialitats, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Neurologia Infantil, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. European Reference Networks for Rare Neurological Diseases (ERN-RND), and Neuromuscular Diseases (ERN-EuroNMD), Institut de Myologie, Paris, France
dc.identifier.wos000489176800052
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record