Show simple item record

 
dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorUdaondo, Patricia
dc.contributor.authorHernández Pascual, Cristina
dc.contributor.authorBrianso Llort, Laura
dc.contributor.authorGarcía-Delpech, Salvador
dc.contributor.authorSimó Servat, Olga
dc.contributor.authorSimó Canonge, Rafael
dc.date.accessioned2020-09-07T11:18:21Z
dc.date.available2020-09-07T11:18:21Z
dc.date.issued2019-11-02
dc.identifier.citationUdaondo P, Hernández C, Briansó-Llort L, García-Delpech S, Simó-Servat O, Simó R. Usefulness of liquid biopsy biomarkers from aqueous humor in predicting Anti-VEGF response in diabetic macular edema: results of a pilot study. J Clin Med. 2019 Nov 2;8(11):1841.
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/11351/5221
dc.descriptionDiabetic macular edema; Anti-VEGF agents; Aqueous humor
dc.description.abstractThe objective was to investigate the usefulness of the “liquid biopsy” of aqueous humor (AH) to predict the clinical response after intravitreal injections (IVT) of anti-VEGF agents for treating diabetic macular edema (DME). For this purpose, AH samples obtained during the first anti-VEGF IVT from 31 type two diabetic patients were analyzed. Patients were classified into three groups according to their anti-VEGF response: rapid responders (n = 11), slow responders (n = 11), and non-responders (n = 9). In addition, patients (n = 7) who showed good response to corticosteroids but a delayed or no response to anti-VEGF therapy were analyzed. Levels of 17 different cytokines, chemokines, and growth factors in AH were measured using a multiplex immunoassay. We found higher concentrations of VEGF in rapid responders to anti-VEGF therapy compared to non-responders. In addition, slow responders to anti-VEGF treatment showed higher levels of inflammatory markers than rapid responders, but did not reach statistical significance. Finally, those patients who responded to corticosteroids but not to anti-VEGF therapy showed significantly lower levels of VEGF than patients with rapid response (p = 0.01). In conclusion, “liquid biopsy” of AH could be useful to determine whether the predominant pathogenic event is primarily angiogenic or inflammatory in nature. This approach would allow physicians to select a more rational and cost-effective treatment. Further studies to validate these preliminary results are warranted.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesJournal of Clinical Medicine;8(11)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectBiòpsia
dc.subjectFactors de creixement fibroblàstic
dc.subjectRetinopatia diabètica
dc.subject.meshLiquid Biopsy
dc.subject.meshMacular Edema
dc.subject.meshVascular Endothelial Growth Factors
dc.subject.mesh/antagonists & inhibitors
dc.titleUsefulness of liquid biopsy biomarkers from aqueous humor in predicting Anti-VEGF response in diabetic macular edema: results of a pilot study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/jcm8111841
dc.subject.decsbiopsia líquida
dc.subject.decsedema macular
dc.subject.decsfactores de crecimiento endotelial vascular
dc.subject.decs/antagonistas & inhibidores
dc.relation.publishversionhttps://www.mdpi.com/2077-0383/8/11/1841
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Udaondo P, García-Delpech S] Department of Ophthalmology, Hospital Universitari i Politècnic La Fe, Valencia, Spain. [Hernández C, Briansó-Llort L, Simó-Servat O, Simó R] Grup de Recerca en Diabetis i metabolisme, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ICSIII), Madrid, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain
dc.identifier.pmid31684007
dc.identifier.wos000502294400084
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F00541
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record