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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorStrauss, Mariana
dc.contributor.authorAcosta-Herrera, Marialbert
dc.contributor.authorAlcaraz, Alexia
dc.contributor.authorCasares-Marfil, Desiré
dc.contributor.authorBosch Nicolau, Pau
dc.contributor.authorLo Presti, María Silvina
dc.contributor.authorMolina Romero, Israel
dc.date.accessioned2021-04-13T07:54:28Z
dc.date.available2021-04-13T07:54:28Z
dc.date.issued2019-11-21
dc.identifier.citationStrauss M, Acosta-Herrera M, Alcaraz A, Casares-Marfil D, Bosch-Nicolau P, Lo Presti MS, et al. Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. Almeida IC, editor. PLoS Negl Trop Dis. 2019 Nov 21;13(11):e0007859.
dc.identifier.issn1935-2735
dc.identifier.urihttp://hdl.handle.net/11351/5843
dc.descriptionChagas disease; IL18
dc.description.abstractHost genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66–0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64–0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied.
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.ispartofseriesPLoS Neglected Tropical Diseases;13(11)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectChagas, Malaltia de
dc.subjectMalalties parasitàries
dc.subjectAmèrica Llatina
dc.subject.meshChagas Disease
dc.subject.meshTrypanosoma cruzi
dc.subject.meshLatin America
dc.titleAssociation of IL18 genetic polymorphisms with Chagas disease in Latin American populations
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1371/journal.pntd.0007859
dc.subject.decsenfermedad de Chagas
dc.subject.decsTrypanosoma cruzi
dc.subject.decsLatinoamérica
dc.relation.publishversionhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007859
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Strauss M, Lo Presti MS] Centro de Estudios e Investigación de la Enfermedad de Chagas y Leishmaniasis, FCM, INICSA-CONICET-UNC, Córdoba, Argentina. [Acosta-Herrera M, Alcaraz A, Casares-Marfil D] Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS Granada, Granada, España. [Bosch-Nicolau P, Molina I] Unitat de Medicina Tropical i Salut Internacional Drassanes, Vall d'Hebron Hospital Universitari, Barcelona, Spain. PROSICS, Barcelona, España
dc.identifier.pmid31751351
dc.identifier.wos000503278100024
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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