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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorLópez-Cano, Carolina
dc.contributor.authorGutiérrez-Carrasquilla, Liliana
dc.contributor.authorSánchez, Enric
dc.contributor.authorGonzález, Jessica
dc.contributor.authorYeramian, Andree
dc.contributor.authorMartí, Raquel
dc.contributor.authorHernández Pascual, Cristina
dc.contributor.authorSimó Canonge, Rafael
dc.date.accessioned2021-04-13T09:40:36Z
dc.date.available2021-04-13T09:40:36Z
dc.date.issued2019-11-01
dc.identifier.citationLópez-Cano C, Gutiérrez-Carrasquilla L, Sánchez E, González J, Yeramian A, Martí R, et al. Sympathetic Hyperactivity and Sleep Disorders in Individuals With Type 2 Diabetes. Front Endocrinol (Lausanne). 2019 Nov 1;10:752.
dc.identifier.issn1664-2392
dc.identifier.urihttp://hdl.handle.net/11351/5844
dc.descriptionType 2 diabetes; Sympathetic hyperactivity; Cardiovascular risk
dc.description.abstractIntroduction: Many studies on the impact of type 2 diabetes mellitus (T2DM) on sleep breathing have shown a higher prevalence and severity of sleep apnea-hypopnea syndrome (SAHS) in those with T2DM. Moreover, an increased activity of the sympathetic nervous system has been described in both pathologies. This cross-sectional study aimed to assess sympathetic activity in patients with T2DM, and to investigate the relationship between sympathetic activity and polysomnographic parameters. Materials and Methods: Thirty-six patients with T2DM without known clinical macrovascular nor pulmonary disease and 11 controls underwent respiratory polygraphy, and their cardiac variability and 24-h urine total metanephrines were measured. Results: SAHS was highly prevalent with a mean apnea-hypopnea index (AHI) in the range of moderate SAHS. In patients with T2DM, the nocturnal concentration of total metanephrines in urine were higher than diurnal levels [247.0 (120.0–1375.0) vs. 210.0 (92.0–670.0), p = 0.039]. The nocturnal total metanephrine concentration was positively and significantly associatedwith the percentage of sleeping time spent with oxygen saturation <90%(CT90). In the entire population and in subjects with T2DM, the multivariate regression analysis showed a direct interaction between the nocturnal concentration of urine metanephrines and the CT90. Conclusion: These findings suggest that the increase in sympathetic activity previously described in patients with T2DM could be mediated through nocturnal breathing disturbances. The diagnosis and treatment of SAHS may influence sympathetic activity disorders and may contribute to an improvement in T2DM and cardiovascular risk.
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Endocrinology;10
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectDiabetis no-insulinodependent
dc.subjectApnea
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshSleep Apnea Syndromes
dc.titleSympathetic Hyperactivity and Sleep Disorders in Individuals With Type 2 Diabetes
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3389/fendo.2019.00752
dc.subject.decsdiabetes mellitus tipo II
dc.subject.decssíndromes de apnea del sueño
dc.relation.publishversionhttps://www.frontiersin.org/articles/10.3389/fendo.2019.00752/full
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[López-Cano C, Gutiérrez-Carrasquilla L, Sánchez E, Yeramian A, Martí R] Endocrinology and Nutrition Department, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova, Obesity, Diabetes and Metabolism Research Group (ODIM), Universitat de Lleida (UdL), Lleida, Spain. [González J] Respiratory Department, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova-Santa María, Translational Research in Respiratory Medicine, Universitat de Lleida (UdL), Lleida, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Hernández C, Simó R] Grup Diabetis i Metabolisme, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei d’Endocrinologia i Nutrició. Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación en Red en Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
dc.identifier.pmid31736881
dc.identifier.wos000496940900001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/1PN/PI12%2F00803
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F00260
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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