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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorMartínez-Trufero, Javier
dc.contributor.authorDe Sande-González, Luis Miguel
dc.contributor.authorLuna, Pablo
dc.contributor.authorMartin-Broto, Javier
dc.contributor.authorÁlvarez, Rosa
dc.contributor.authorMarquina, Gloria
dc.contributor.authorValverde Morales, Claudia Maria
dc.date.accessioned2021-06-01T11:26:30Z
dc.date.available2021-06-01T11:26:30Z
dc.date.issued2021-02-14
dc.identifier.citationMartínez-Trufero J, De Sande-González LM, Luna P, Martin-Broto J, Álvarez R, Marquina G, et al. A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study. Cancers. 2021 Feb 14;13(4):792.
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/11351/6001
dc.descriptionL-sarcoma; Growth modulation index; Sarcoma
dc.description.abstractThe aim of this study was to identify an easily reliable prognostic score that selects the subset of advanced soft tissue sarcoma (ASTS) patients with a higher benefit with trabectedin in terms of time to progression and overall survival. A retrospective series of 357 patients with ASTS treated with trabectedin as second- or further-line in 19 centers across Spain was analyzed. First, it was confirmed that patients with high growth modulation index (GMI > 1.33) were associated with the better clinical outcome. Univariate and multivariate analyses were performed to identify factors associated with a GMI > 1.33. Thus, GEISTRA score was based on metastasis free-interval (MFI ≤ 9.7 months), Karnofsky < 80%, Non L-sarcomas and better response in the previous systemic line. The median GMI was 0.82 (0–69), with 198 patients (55%) with a GMI < 1, 41 (11.5%) with a GMI 1–1.33 and 118 (33.1%) with a GMI > 1.33. The lowest GEISTRA score showed a median of time-to-progression (TTP) and overall survival (OS) of 5.7 and 19.5 months, respectively, whereas it was 1.8 and 3.1 months for TTP and OS, respectively, for the GEISTRA 4 score. This prognostic tool can contribute to better selecting candidates for trabectedin treatment in ASTS.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesCancers;13(4)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectTumors de parts toves
dc.subjectMedicaments - Eficàcia
dc.subject.meshSoft Tissue Neoplasms
dc.subject.mesh/drug therapy
dc.subject.meshEffectiveness
dc.titleA Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/cancers13040792
dc.subject.decsneoplasias de los tejidos blandos
dc.subject.decs/farmacoterapia
dc.subject.decsefectividad
dc.relation.publishversionhttps://doi.org/10.3390/cancers13040792
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Martínez-Trufero J] Javier Martinez-Trufero, Medical Oncology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain. [De Sande-González LM] Medical Oncology Department, Complejo Asistencial Universitario de Leon, Leon, Spain. [Luna P] Medical Oncology Department, Hospital Universitario Son Espases, Palma de Mallorca, Spain. [Martin-Broto J] Medical Oncology Department, Hospital Universitario Virgen del Rocio, Instituto de Biomedicina de Sevilla (IBiS; CSIC, US, HUVR), Sevilla, Spain. [Álvarez R] Medical Oncology Department, Hospital Universitario Gregorio Marañon, Madrid, Spain. [Marquina G] Medical Oncology Department, Hospital Universitario Clinico San Carlos, Madrid, Spain. [Valverde-Morales CM] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid33672857
dc.identifier.wos000623337400001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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