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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRamiro Pascual, Laura
dc.contributor.authorAbraira del Fresno, Laura
dc.contributor.authorQuintana Luque, Manuel
dc.contributor.authorGarcia Rodriguez, Paula
dc.contributor.authorSantamarina Pérez, Estevo
dc.contributor.authorAlvarez Sabin, José
dc.contributor.authorBustamante Rangel, Alejandro
dc.contributor.authorMontaner Villalonga, Joan
dc.date.accessioned2021-06-09T06:38:54Z
dc.date.available2021-06-09T06:38:54Z
dc.date.issued2021-02-10
dc.identifier.citationRamiro L, Abraira L, Quintana M, García-Rodríguez P, Santamarina E, Álvarez-Sabín J, et al. Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke. Life. 2021 Feb 10;11(2):135
dc.identifier.issn2075-1729
dc.identifier.urihttp://hdl.handle.net/11351/6038
dc.descriptionBiomarker; Endostatin; Ischemic stroke
dc.description.abstractStroke is a major cause of disability and death globally, and prediction of mortality represents a crucial challenge. We aimed to identify blood biomarkers measured during acute ischemic stroke that could predict long-term mortality. Nine hundred and forty-one ischemic stroke patients were prospectively recruited in the Stroke-Chip study. Post-stroke mortality was evaluated during a median 4.8-year follow-up. A 14-biomarker panel was analyzed by immunoassays in blood samples obtained at hospital admission. Biomarkers were normalized and standardized using Z-scores. Multiple Cox regression models were used to identify clinical variables and biomarkers independently associated with long-term mortality and mortality due to stroke. In the multivariate analysis, the independent predictors of long-term mortality were age, female sex, hypertension, glycemia, and baseline National Institutes of Health Stroke Scale (NIHSS) score. Independent blood biomarkers predictive of long-term mortality were endostatin > quartile 2, tumor necrosis factor receptor-1 (TNF-R1) > quartile 2, and interleukin (IL)-6 > quartile 2. The risk of mortality when these three biomarkers were combined increased up to 69%. The addition of the biomarkers to clinical predictors improved the discrimination (integrative discriminative improvement (IDI) 0.022 (0.007–0.048), p < 0.001). Moreover, endostatin > quartile 3 was an independent predictor of mortality due to stroke. Altogether, endostatin, TNF-R1, and IL-6 circulating levels may aid in long-term mortality prediction after stroke.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesLife;11(2)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectMarcadors bioquímics
dc.subjectPrognosi
dc.subjectIsquèmia cerebral - Mortalitat
dc.subject.meshPrognosis
dc.subject.meshBiomarkers
dc.subject.meshBrain Ischemia
dc.subject.mesh/mortality
dc.titleBlood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/life11020135
dc.subject.decspronóstico
dc.subject.decsbiomarcadores
dc.subject.decsisquemia cerebral
dc.subject.decs/mortalidad
dc.relation.publishversionhttps://www.mdpi.com/2075-1729/11/2/135
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Ramiro L, García-Rodríguez P] Neurovascular Research Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Abraira L, Quintana M, Santamarina E] Unitat d’Epilèpsia, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Álvarez-Sabín J] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Montaner J] Neurovascular Research Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC/University of Seville & Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain
dc.identifier.pmid33578805
dc.identifier.wos000622702300001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F00804
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PERIS2016-2020/201702
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0019%2F0021
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/IFI17%2F00012
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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