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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorGómez-Junyent, Joan
dc.contributor.authorLora-Tamayo, Jaime
dc.contributor.authorBaraia-Etxaburu, Josu
dc.contributor.authorSánchez-Somolinos, Mar
dc.contributor.authorIribarren, Jose Antonio
dc.contributor.authorRodríguez Pardo, Ma Dolores
dc.contributor.authorPigrau Serrallach, Carles
dc.date.accessioned2021-07-21T12:57:59Z
dc.date.available2021-07-21T12:57:59Z
dc.date.issued2021-01-26
dc.identifier.citationGómez-Junyent J, Lora-Tamayo J, Baraia-Etxaburu J, Sánchez-Somolinos M, Iribarren JA, Rodriguez-Pardo D, et al. Implant removal in the management of prosthetic joint infection by staphylococcus aureus: Outcome and predictors of failure in a large retrospective multicenter study. Antibiotics. 2021 Jan 26;10(2):118.
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/11351/6199
dc.descriptionStaphylococcus aureus; Implant removal; Prosthetic joint infection
dc.description.abstractObjectives: To compare the characteristics and outcomes of cases with acute prosthetic joint infection (PJI; early post-surgical or hematogenous) by Staphylococcus aureus managed with implant removal (IRm) or debridement and retention (DAIR). To analyze the outcomes of all cases managed with IRm (initially or after DAIR failure). Methods: Retrospective, multicenter, cohort study of PJI by S. aureus (2003–2010). Overall failure included mortality within 60 days since surgery and local failure due to staphylococcal persistence/relapse. Results: 499 cases, 338 initially managed with DAIR, 161 with IRm. Mortality was higher in acute PJI managed initially with IRm compared to DAIR, but not associated with the surgical procedure, after propensity score matching. Underlying conditions, hemiarthroplasty, and methicillin-resistant S. aureus were risk factors for mortality. Finally, 249 cases underwent IRm (88 after DAIR failure); overall failure was 15.6%. Local failure (9.3%) was slightly higher in cases with several comorbidities, but independent of previous DAIR, type of IRm, and rifampin treatment. Conclusions: In a large multicenter study of S. aureus PJI managed with IRm, failure was low, but mortality significant, especially in cases with acute PJI and underlying conditions, but not associated with the IRm itself. Rifampin efficacy was limited in this setting.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesAntibiotics;10(2)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectArticulacions artificials
dc.subjectInfeccions per estafilococs daurats
dc.subjectAntibiòtics macròlids - Ús terapèutic
dc.subject.meshProsthesis-Related Infections
dc.subject.meshStaphylococcal Infections
dc.subject.meshRifampin
dc.subject.mesh/therapeutic use
dc.titleImplant Removal in the Management of Prosthetic Joint Infection by Staphylococcus aureus: Outcome and Predictors of Failure in a Large Retrospective Multicenter Study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/antibiotics10020118
dc.subject.decsinfecciones relacionadas con prótesis
dc.subject.decsinfecciones estafilocócicas
dc.subject.decsrifampicina
dc.subject.decs/uso terapéutico
dc.relation.publishversionhttps://www.mdpi.com/2079-6382/10/2/118
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Gómez-Junyent J] Department of Infectious Diseases, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, L’Hospitalet de Llobregat, Spain. [Lora-Tamayo J] Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain. [Baraia-Etxaburu J] Department of Infectious Diseases, Hospital Universitario de Basurto, Bilbao, Spain. [Sánchez-Somolinos M] Department of Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Iribarren JA] Department of Infectious Diseases, Hospital Universitario Donostia, Universidad del País Vasco (EHU/UPV), San Sebastián, Spain. IIS BioDonostia, San Sebastián, Spain. [Rodriguez-Pardo D, Pigrau C] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid33530523
dc.identifier.wos000622011200001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0016%2F0005
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/FPU014%2F03124
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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