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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBeaulieu, Marie-Eve
dc.contributor.authorCastillo, Francisco
dc.contributor.authorSoucek, Laura
dc.date.accessioned2021-09-01T11:04:56Z
dc.date.available2021-09-01T11:04:56Z
dc.date.issued2020-04-22
dc.identifier.citationBeaulieu ME, Castillo F, Soucek L. Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein. Cells. 2020 Apr 22;9(4):1038.
dc.identifier.issn2073-4409
dc.identifier.urihttp://hdl.handle.net/11351/6252
dc.descriptionMyc; Drug discovery; Protein–DNA interactions
dc.description.abstractMyc is a transcription factor driving growth and proliferation of cells and involved in the majority of human tumors. Despite a huge body of literature on this critical oncogene, our understanding of the exact molecular determinants and mechanisms that underlie its function is still surprisingly limited. Indubitably though, its crucial and non-redundant role in cancer biology makes it an attractive target. However, achieving successful clinical Myc inhibition has proven challenging so far, as this nuclear protein is an intrinsically disordered polypeptide devoid of any classical ligand binding pockets. Indeed, Myc only adopts a (partially) folded structure in some contexts and upon interacting with some protein partners, for instance when dimerizing with MAX to bind DNA. Here, we review the cumulative knowledge on Myc structure and biophysics and discuss the implications for its biological function and the development of improved Myc inhibitors. We focus this biophysical walkthrough mainly on the basic region helix–loop–helix leucine zipper motif (bHLHLZ), as it has been the principal target for inhibitory approaches so far.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesCells;9(4)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectMedicaments - Desenvolupament
dc.subjectADN - Interaccions de les proteïnes
dc.subjectOncogens
dc.subject.meshProto-Oncogene Proteins c-myc
dc.subject.meshIntrinsically Disordered Proteins
dc.subject.meshDrug Evaluation, Preclinical
dc.titleStructural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/cells9041038
dc.subject.decsproteínas protooncogénicas c-myc
dc.subject.decsproteínas intrínsecamente desestructuradas
dc.subject.decsevaluación preclínica de medicamentos
dc.relation.publishversionhttps://www.mdpi.com/2073-4409/9/4/1038
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Beaulieu ME, Castillo F] Peptomyc, Barcelona, Spain. [Soucek L] Peptomyc, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid32331235
dc.identifier.wos000535559500249
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/872212
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/617473
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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