dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Lahiguera, Álvaro |
dc.contributor.author | Hyroššová, Petra |
dc.contributor.author | Figueras, Agnès |
dc.contributor.author | Garzón, Diana |
dc.contributor.author | Moreno, Roger |
dc.contributor.author | Soto-Cerrato, Vanessa |
dc.contributor.author | Serra Elizalde, Violeta |
dc.date.accessioned | 2021-09-09T06:12:09Z |
dc.date.available | 2021-09-09T06:12:09Z |
dc.date.issued | 2020-06-08 |
dc.identifier.citation | Lahiguera Á, Hyroššová P, Figueras A, Garzón D, Moreno R, Soto-Cerrato V, et al. Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors. EMBO Mol Med. 2020 Jun 8;12:e11217. |
dc.identifier.issn | 1757-4684 |
dc.identifier.uri | https://hdl.handle.net/11351/6283 |
dc.description | Inhibidors de la PARP; Metabolisme del càncer; Metformina |
dc.description.sponsorship | This study has been funded by the Ministerio de Ciencia, Innovación y Universidades, which is part of the Agencia Estatal de Investigación (AEI), through the project SAF2017-85869-R (cofunded by the European Regional Development Fund (ERDF), a way to build Europe) to FV and BFU2015-66030-R to JCP; by the FIS PI15/00854 and FIS PI16/01898 (Instituto Carlos III, cofunded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe) to MAP and AVillanueva and with the support of the Secretariat for Universities and Research of the Department of Business and Knowledge of the Government of Catalonia (2017SGR449) to FV. We thank the CERCA Program/Generalitat de Catalunya for their institutional support. We particularly wish to acknowledge the collaboration of the patients and the IDIBGI Biobank (Biobanc IDIBGI, B.0000872), which is part of the Spanish National Biobank Network and the Xarxa de Bancs de Tumors de Catalunya (XBTC), financed by the Pla Director d'Oncologia de Catalunya, Spain. We thank Cristina Saura (Breast Cancer & Melanoma Group) and people from the Experimental Therapeutics Group at VHIO and Sara González (Unitat de Diagnòstic Molecular, ICO-Duran i Reynals). We thank H. Simon, R. Bartrons, and A. Manzano (Universitat de Barcelona) and A. Vaquero (IDIBELL) for reagents. |
dc.language.iso | eng |
dc.publisher | Wiley |
dc.relation.ispartofseries | EMBO Molecular Medicine;12 |
dc.rights | Attribution 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.source | Scientia |
dc.subject | Ovaris - Càncer |
dc.subject | Medicaments antineoplàstics - Ús terapèutic |
dc.subject | Recombinació genètica |
dc.subject.mesh | Ovarian Neoplasms |
dc.subject.mesh | /drug therapy |
dc.subject.mesh | Homologous Recombination |
dc.title | Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.15252/emmm.201911217 |
dc.subject.decs | neoplasias ováricas |
dc.subject.decs | /farmacoterapia |
dc.subject.decs | recombinación homóloga |
dc.relation.publishversion | https://doi.org/10.15252/emmm.201911217 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Lahiguera Á, Figueras A, Garzón D, Moreno R] Program Against Cancer Therapeutic Resistance (ProCURE), Institut Català d'Oncologia, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain. Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. [Hyroššová P] Departament de Ciències Fisiològiques, Universitat de Barcelona, Barcelona, Spain. [Soto-Cerrato V] Departament de Patologia i Terapèutica Experimental, Universitat de Barcelona, Barcelona, Spain. [Serra V] Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. CIBERONC, Instituto de Salud Carlos III, Madrid, Spain |
dc.identifier.pmid | 32400970 |
dc.identifier.wos | 000531867100001 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2013-2016/SAF2017-85869-R |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2013-2016/BFU2015-66030-R |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F00854 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F01898 |
dc.relation.projectid | info:eu-repo/grantAgreement/ES/PERIS2016-2020/2017SGR449 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |