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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBenavente Norza, Sergio
dc.contributor.authorSanchez Garcia, Almudena
dc.contributor.authorNaches Garcia, Silvia
dc.contributor.authorLorente Guerrero, Juan
dc.contributor.authorLleonart Pajarin, Matilde
dc.date.accessioned2021-09-10T11:46:16Z
dc.date.available2021-09-10T11:46:16Z
dc.date.issued2020-10-23
dc.identifier.citationBenavente S, Sánchez-García A, Naches S, LLeonart ME, Lorente J. Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies. Front Oncol. 2020 Oct 23;10:582884.
dc.identifier.issn2234-943X
dc.identifier.urihttps://hdl.handle.net/11351/6301
dc.descriptionCancer; Immunotherapy; Radiotherapy
dc.description.abstractAdvances in immunotherapy have achieved remarkable clinical outcomes in tumors with low curability, but their effects are limited, and increasing evidence has implicated tumoral and non-tumoral components of the tumor microenvironment as critical mediators of cancer progression. At the same time, the clinical successes achieved with minimally invasive and optically-guided surgery and image-guided and ablative radiation strategies have been successfully implemented in clinical care. More effective, localized and safer treatments have fueled strong research interest in radioimmunotherapy, which has shown the potential immunomodulatory effects of ionizing radiation. However, increasingly more observations suggest that immunosuppressive changes, metabolic remodeling, and angiogenic responses in the local tumor microenvironment play a central role in tumor recurrence. In this review, we address challenges to identify responders vs. non-responders to the immune checkpoint blockade, discuss recent developments in combinations of immunotherapy and radiotherapy for clinical evaluation, and consider the clinical impact of immunosuppressive changes in the tumor microenvironment in the context of surgery and radiation. Since the therapy-induced modulation of the tumor microenvironment presents a multiplicity of forms, we propose that overcoming microenvironment related resistance can become clinically relevant and represents a novel strategy to optimize treatment immunogenicity and improve patient outcome.
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Oncology;10
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCàncer - Tractament
dc.subjectFisiologia cel·lular
dc.subject.meshTumor Microenvironment
dc.subject.meshNeoplasms
dc.subject.mesh/therapy
dc.titleTherapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3389/fonc.2020.582884
dc.subject.decsmicroambiente tumoral
dc.subject.decsneoplasias
dc.subject.decs/terapia
dc.relation.publishversionhttps://doi.org/10.3389/fonc.2020.582884
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Benavente S] Servei d’Oncologia Radioteràpica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Sánchez-García A] Grup de Recerca biomèdica amb cèl·lules mare del càncer, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Naches S, Lorente J] Servei d’Otorrinolaringologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [LLeonart ME] Grup de Recerca biomèdica amb cèl·lules mare del càncer, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Spanish Biomedical Research Network Centre in Oncology, CIBERONC, Barcelona, Spain
dc.identifier.pmid33194719
dc.identifier.wos000585935700001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F01262
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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