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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorZunder, Stéphanie M.
dc.contributor.authorPérez López, Raquel
dc.contributor.authorde Kok, Bente M.
dc.contributor.authorRaciti, Maria Vittoria
dc.contributor.authorvan Pelt, Gabi W.
dc.contributor.authorDienstmann, Rodrigo
dc.contributor.authorGarcia Ruiz, Alonso
dc.contributor.authorNuciforo, Paolo Giovanni
dc.date.accessioned2021-10-29T07:38:58Z
dc.date.available2021-10-29T07:38:58Z
dc.date.issued2020-12-01
dc.identifier.citationZunder SM, Perez-Lopez R, de Kok BM, Raciti MV, van Pelt GW, Dienstmann R, et al. Correlation of the tumour-stroma ratio with diffusion weighted MRI in rectal cancer. Eur J Radiol. 2020 Dec 1;133:109345.
dc.identifier.issn0720-048X
dc.identifier.urihttp://hdl.handle.net/11351/6484
dc.descriptionMagnetic Resonance Imaging; Rectal neoplasms; Tumor Microenvironment
dc.description.abstractObjective This study evaluated the correlation between intratumoural stroma proportion, expressed as tumour-stroma ratio (TSR), and apparent diffusion coefficient (ADC) values in patients with rectal cancer. Methods This multicentre retrospective study included all consecutive patients with rectal cancer, diagnostically confirmed by biopsy and MRI. The training cohort (LUMC, Netherlands) included 33 patients and the validation cohort (VHIO, Spain) 69 patients. Two observers measured the mean and minimum ADCs based on single-slice and whole-volume segmentations. The TSR was determined on diagnostic haematoxylin & eosin stained slides of rectal tumour biopsies. The correlation between TSR and ADC was assessed by Spearman correlation ( r s ). Results The ADC values between stroma-low and stroma-high tumours were not significantly different. Intra-class correlation (ICC) demonstrated a good level of agreement for the ADC measurements, ranging from 0.84–0.86 for single slice and 0.86–0.90 for the whole-volume protocol. No correlation was observed between the TSR and ADC values, with ADC mean r s = -0.162 ( p= 0.38) and ADC min r s = 0.041 ( p= 0.82) for the single-slice and r s = -0.108 ( p= 0.55) and r s = 0.019 ( p= 0.92) for the whole-volume measurements in the training cohort, respectively. Results from the validation cohort were consistent; ADC mean r s = -0.022 ( p= 0.86) and ADC min r s = 0.049 ( p= 0.69) for the single-slice and r s = -0.064 ( p= 0.59) and r s = -0.063 ( p= 0.61) for the whole-volume measurements. Conclusions Reproducibility of ADC values is good. Despite positive reports on the correlation between TSR and ADC values in other tumours, this could not be confirmed for rectal cancer.
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesEuropean Journal of Radiology;133
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectRecte - Càncer - Tractament
dc.subjectRessonància magnètica
dc.subjectAvaluació de resultats (Assistència sanitària)
dc.subject.meshRectal Neoplasms
dc.subject.meshDiffusion Magnetic Resonance Imaging
dc.subject.meshReproducibility of Results
dc.titleCorrelation of the tumour-stroma ratio with diffusion weighted MRI in rectal cancer
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.ejrad.2020.109345
dc.subject.decsneoplasias del recto
dc.subject.decsimagen de resonancia magnética de difusión
dc.subject.decsreproducibilidad de los resultados
dc.relation.publishversionhttps://doi.org/10.1016/j.ejrad.2020.109345
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Zunder SM] Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. Department of Medical Oncology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. [Perez-Lopez R, Raciti MV, Garcia-Ruiz A] Radiomics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [de Kok BM] Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC Leiden, The Netherlands. [van Pelt GW] Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. [Dienstmann R] Department of Oncology Data Science, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Nuciforo P] Department of Molecular Oncology Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.identifier.pmid33120239
dc.identifier.wos000605118300004
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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