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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorGoasguen, Jean E.
dc.contributor.authorBennett, John M.
dc.contributor.authorBain, Barbara J.
dc.contributor.authorBrunning, Richard
dc.contributor.authorZini, Gina
dc.contributor.authorVallespi Sole, Maria Teresa
dc.date.accessioned2021-11-05T06:58:34Z
dc.date.available2021-11-05T06:58:34Z
dc.date.issued2020-11
dc.identifier.citationGoasguen JE, Bennett JM, Bain BJ, Brunning R, Zini G, Vallespi M, et al. The role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm. Br J Haematol. 2020 Nov;191(3):497–504.
dc.identifier.issn1365-2141
dc.identifier.urihttp://hdl.handle.net/11351/6501
dc.descriptionEosinophil; Morphology; Myeloid neoplasia
dc.description.abstractMorphological features of eosinophils in patients with reactive eosinophilia (28 patients) and clonal eosinophilia (26 patients) have been compared with each other and with the eosinophil characteristics of healthy volunteers (three subjects) and of patients with the idiopathic hypereosinophilic syndrome (three patients). Morphological features, assessed in isolation from other haematological abnormalities, were found to have poor specificity for a myeloid neoplasm. The most useful feature was the presence of basophilic granules in mature eosinophils, which was associated particularly with acute myeloid leukaemia with inv(16). Marked reduction in granules occurred more often in some subsets of the myeloid neoplasm group but nevertheless was lacking in specificity since it was not infrequently seen in reactive eosinophilia. Although experienced morphologists more often considered that a myeloid neoplasm was likely in patients in whom this was the diagnosis (69%), myeloid neoplasia was also considered likely in a considerable proportion (39%) of patients with reactive eosinophilia. Morphological abnormalities of eosinophils therefore cannot be assessed in isolation in seeking to make a diagnosis of a myeloid neoplasm. Morphology is, however, needed and should be integrated with the results of other investigations.
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesBritish Journal of Haematology;191(3)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectLeucèmia mieloide
dc.subjectEosinofília
dc.subject.meshLeukemia, Myeloid
dc.subject.meshEosinophilia
dc.subject.mesh/pathology
dc.titleThe role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1111/bjh.17026
dc.subject.decsleucemia mieloide
dc.subject.decseosinofilia
dc.subject.decs/patología
dc.relation.publishversionhttps://doi.org/10.1111/bjh.17026
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Goasguen JE] University of Rennes, Rennes, France. [Bennett JM] University of Rochester Medical Center, Rochester, NY, USA. [Bain BJ] St Mary’s Hospital Campus of Imperial College, London, UK. [Brunning R] University of Minnesota, Minneapolis, MN, USA. [Zini G] Fondazione Policlinico Universitario A. Gemelli IRCCS and Università Cattolica del Sacro Cuore, Rome, Italy. [Vallespi MT] Department of Haematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.identifier.pmid32860711
dc.identifier.wos000563811700001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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