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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorMasana, Lluís
dc.contributor.authorCorreig Fraga, Eudald
dc.contributor.authorIbarretxe, Daiana
dc.contributor.authorAnoro, Eva
dc.contributor.authorArroyo, Juan Antonio
dc.contributor.authorJericó, Carlos
dc.contributor.authorUrquizu Padilla, Maria
dc.date.accessioned2021-12-01T07:24:00Z
dc.date.available2021-12-01T07:24:00Z
dc.date.issued2021-03-30
dc.identifier.citationMasana L, Correig E, Ibarretxe D, Anoro E, Arroyo JA, Jericó C, et al. Low HDL and high triglycerides predict COVID-19 severity. Sci Rep. 2021 Mar 30;11:7217.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11351/6629
dc.descriptionCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Dyslipidaemias; Risk factors
dc.description.abstractLipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.
dc.language.isoeng
dc.publisherNature Research
dc.relation.ispartofseriesScientific Reports;11
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCOVID-19 (Malaltia) - Etiologia
dc.subjectLípids de la sang
dc.subjectPrognosi
dc.subject.meshCoronavirus Infections
dc.subject.meshLipids
dc.subject.mesh/blood
dc.subject.meshPredictive Value of Tests
dc.titleLow HDL and high triglycerides predict COVID-19 severity
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41598-021-86747-5
dc.subject.decsinfecciones por Coronavirus
dc.subject.decslípidos
dc.subject.decs/sangre
dc.subject.decsvalor predictivo de las pruebas
dc.relation.publishversionhttps://doi.org/10.1038/s41598-021-86747-5
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Masana L, Ibarretxe D] Facultat de Medicina, Universitat Rovira I Virgili, LIPIDCAS, University Hospital Sant Joan, IISPV, CIBERDEM, 43201 Reus, Spain. [Correig E] Statistics Department, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira I Virgili, Reus, Spain. [Anoro E] LIPIDCAS, Pius Hospital Valls, Valls, Spain. [Arroyo JA] Lipid Unit, University Hospital Santa Creu i Sant Pau, Barcelona Autonomous University, Barcelona, Spain. [Jericó C] Lipid Unit, Hospital Moises Broggi, Consorci Sanitari Integral, Sant Joan Despí, Spain. [Urquizu-Padilla M] Unitat de Lípids, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid33785815
dc.identifier.wos000636270800033
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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