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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRemuzgo-Martínez, Sara
dc.contributor.authorGenre, Fernanda
dc.contributor.authorPulito-Cueto, Verónica
dc.contributor.authorAtienza-Mateo, Belén
dc.contributor.authorMora Cuesta, Víctor Manuel
dc.contributor.authorIturbe Fernández, David
dc.contributor.authorBerastegui Garcia, Cristina
dc.date.accessioned2021-12-07T12:40:55Z
dc.date.available2021-12-07T12:40:55Z
dc.date.issued2021-05
dc.identifier.citationRemuzgo-Martínez S, Genre F, Pulito-Cueto V, Atienza-Mateo B, Mora Cuesta VM, Iturbe Fernández D, et al. Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease. Biomedicines. 2021 May;9:458.
dc.identifier.issn2227-9059
dc.identifier.urihttp://hdl.handle.net/11351/6659
dc.descriptionBiomarker; Interstitial lung disease; Vascular endothelial growth factor
dc.description.abstractThe search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesBiomedicines;9
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectPulmons - Malalties - Aspectes genètics
dc.subjectProteïnes quinases - Receptors
dc.subject.meshLung Diseases, Interstitial
dc.subject.mesh/genetics
dc.subject.meshReceptors, Vascular Endothelial Growth Factor
dc.titleRole of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/biomedicines9050458
dc.subject.decsenfermedades pulmonares intersticiales
dc.subject.decs/genética
dc.subject.decsreceptores del factor de crecimiento del endotelio vascular
dc.relation.publishversionhttps://doi.org/10.3390/biomedicines9050458
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.identifier.pmid33922301
dc.identifier.wos000653399100001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0012%2F0009
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CP16%2F00033
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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