Metabolic alterations were among the first discovered hallmarks of cancer. They were first described 90 years ago when Otto Warburg realized that cancer cells in culture had a relatively increased metabolic rate (the Warburg hypothesis). It has been proposed that the drastic changes seen in cancer metabolism are in part attributed to mutations in the mtDNA, metabolic reprogramming, or mitochondrial dysfunction. However, novel players in cancer metabolism are emerging.
Cancer resistance; Cancer stem cell; Therapy
Kondoh H, Castellvi J, LLeonart ME. Editorial: How Do Metabolism, Angiogenesis, and Hypoxia Modulate Resistance? Front Oncol. 2021 Apr;11:671222.
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