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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRoca, Neus
dc.contributor.authorMartínez Martínez, Cristina
dc.contributor.authorJatem-Escalante, Elias
dc.contributor.authorMadrid Aris, Alvaro Domingo
dc.contributor.authorLópez González, Mercedes
dc.contributor.authorSegarra Medrano, Alfons
dc.date.accessioned2021-12-17T13:30:56Z
dc.date.available2021-12-17T13:30:56Z
dc.date.issued2021-03-30
dc.identifier.citationRoca N, Martinez C, Jatem E, Madrid A, Lopez M, Segarra A. Activation of the acute inflammatory phase response in idiopathic nephrotic syndrome: association with clinicopathological phenotypes and with response to corticosteroids. Clin Kidney J. 2021 Apr 30;14(4):1207–15.
dc.identifier.issn2048-8505
dc.identifier.urihttp://hdl.handle.net/11351/6712
dc.descriptionGlomerulosclerosis; Inflammation; Nephrotic syndrome
dc.description.abstractBackground Data on the activation of the acute inflammatory response and its clinicopathological associations in idiopathic nephrotic syndrome (INS) are scarce and discordant. Objective To analyse the associations between the activation of the inflammatory response, the clinicopathological characteristics of disease and the response to treatment with steroids in patients with INS. Methods A total of 101 patients with INS due to minimal change disease (MCD; n = 44), focal segmental glomerulosclerosis (FSGS; n = 33) and membranous nephropathy (MN; n = 24) and 50 healthy controls were included. At diagnosis, we measured the levels of haemopexin (Hx), haptoglobin (Hgl), interleukin-6 (IL-6), soluble urokinase-type plasminogen activator receptor (suPAR), tumour necrosis factor-α (TNF-α), soluble IL-1 receptor, interferon-γ and C-reactive protein. We analysed their clinicopathological associations. In MCD and FSGS patients, we determined the association between the levels of these variables and steroid resistance. Results The levels of Hx, Hgl, TNF-α, suPAR and IL-6 were higher in patients with INS than in healthy controls, and were not associated with proteinuria, estimated glomerular filtration rate or serum albumin. In MCD and FSGS patients, Hx, Hgl, IL-6 and TNF-α levels were similar and significantly higher than in MN patients. In patients with MCD and FSGS, multivariate analyses identified FSGS and the levels of Hx, Hgl or IL-6 as independent predictors of steroid resistance. Conclusions The activation of the inflammatory response in patients with INS is heterogeneous and more prevalent in MCD or FSGS patients than in those with MN. In MCD and FSGS, elevated levels of Hx, Hgl or IL-6 are independently associated with steroid resistance.
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofseriesClinical Kidney Journal;14(4)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectRonyons - Malalties - Tractament
dc.subjectAntiinflamatoris - Ús terapèutic
dc.subjectResistència als medicaments
dc.subject.meshNephrotic Syndrome
dc.subject.mesh/drug therapy
dc.subject.meshDrug Resistance
dc.subject.meshAnti-Inflammatory Agents
dc.titleActivation of the acute inflammatory phase response in idiopathic nephrotic syndrome: association with clinicopathological phenotypes and with response to corticosteroids
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1093/ckj/sfaa247
dc.subject.decssíndrome nefrótico
dc.subject.decs/farmacoterapia
dc.subject.decsresistencia a medicamentos
dc.subject.decsantiinflamatorios
dc.relation.publishversionhttps://doi.org/10.1093/ckj/sfaa247
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Roca N] Paediatric Nephrology Department, Hospital Universitari de Vic, Universitat de Vic, Barcelona, Spain. [Martinez C] Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Jatem E] Nephrology Department, Hospital Universitario Arnau de Vilanova, Lleida, Spain. [Madrid A] Paediatric Nephrology Department, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain. [Lopez M] Servei de Nefrologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Segarra A] Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain. Nephrology Department, Hospital Universitario Arnau de Vilanova, Lleida, Spain
dc.identifier.pmid33841866
dc.identifier.wos000642298600019
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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