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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBastida, Guillermo
dc.contributor.authorHerrera de Guise, Claudia Maria
dc.contributor.authorAlgaba, Alicia
dc.contributor.authorBer Nieto, Yolanda
dc.contributor.authorSoares, Jose Manuel
dc.contributor.authorRobles Alonso, Virginia
dc.date.accessioned2022-01-17T07:00:20Z
dc.date.available2022-01-17T07:00:20Z
dc.date.issued2021-05-22
dc.identifier.citationBastida G, Herrera-de Guise C, Algaba A, Ber Nieto Y, Soares JM, Robles V, et al. Sucrosomial Iron Supplementation for the Treatment of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients Refractory to Oral Iron Treatment. Nutrients. 2021 May 22;13(6):1770.
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11351/6808
dc.descriptionInflammatory bowel disease; Iron deficiency; Iron supplementation
dc.description.abstractIron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment of choice, but are not always well tolerated. Sucrosomial® iron (SI) may represent an alternative. This prospective study assessed the tolerability and effectiveness of SI, and quality of life (QoL) of IDA-IBD patients who were intolerant to oral iron salts. The study included 52 individuals treated with 1 capsule/day for 12 weeks. Tolerability was assessed through a gastrointestinal symptom severity questionnaire. Hemoglobin (Hb) levels and clinical symptoms of IDA were analyzed. QoL was assessed using IBDQ-9 and EuroQoL questionnaires. The percentage of patients with excellent/good health increased from 42.9% to 94.3%. Mean Hb concentration significantly increased at all follow-up visits (p < 0.05). Almost all participants (96.9%) were adherent to the study medication. Patients’ QoL improved (IBDQ-9: from 60.9 to 65.5). Patients also improved in mobility (71.8% to 78.1%), usual activities (51.3% to 68.7%), pain/discomfort (41.0% to 53.1%), and extreme depression/anxiety problems (7.7% to 3.2%); they worsened in self-care (100% to 90.6%), but perceived an enhancement in their global health [EQ-VAS score: 61.9 (±26.1) to 66.9 (±20.3)]. SI was well tolerated and improved IDA symptoms, IBD activity, and patients’ QoL. In conclusion, SI should be considered in IDA–IBD patients.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesNutrients;13(6)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectIntestins - Inflamació - Tractament
dc.subjectAnèmia ferropènica - Tractament
dc.subjectFerro - Metabolisme - Ús terapèutic
dc.subject.meshInflammatory Bowel Diseases
dc.subject.meshAnemia, Iron-Deficiency
dc.subject.meshIron
dc.subject.mesh/administration & dosage
dc.titleSucrosomial Iron Supplementation for the Treatment of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients Refractory to Oral Iron Treatment
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/nu13061770
dc.subject.decsenfermedad inflamatoria intestinal
dc.subject.decsanemia ferropénica
dc.subject.decshierro
dc.subject.decs/administración & dosificación
dc.relation.publishversionhttps://doi.org/10.3390/nu13061770
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Bastida G] Department of Gastroenterology, CIBEREHD, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain. [Herrera-de Guise C, Robles V] Unitat d'Atenció a la Colitis de Crohn, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Algaba A] Department of Gastroenterology, Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), Hospital Universitario de Fuenlabrada, 28046 Madrid, Spain. [Ber Nieto Y] Department of Gastroenterology, Hospital Universitario San Jorge, 22004 Huesca, Spain. [Soares JM] Department of Gastroenterology, Hospital Pedro Hispano, 4454-509 Matosinhos, Portugal
dc.identifier.pmid34067320
dc.identifier.wos000666753400001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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