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dc.contributorHospital Universitari de Girona Dr Josep Trueta
dc.contributor.authorNetchine, Irene
dc.contributor.authorvan der Steen, Manouk
dc.contributor.authorLopez-Bermejo, Abel
dc.contributor.authorKoledova, Ekaterina
dc.contributor.authorMaghnie, Mohamad
dc.date.accessioned2022-01-24T13:12:34Z
dc.date.available2022-01-24T13:12:34Z
dc.date.issued2021-05-13
dc.identifier.citationNetchine I, van der Steen M, López-Bermejo A, Koledova E, Maghnie M. New Horizons in Short Children Born Small for Gestational Age. Front Pediatr. 2021 May 13;9:655931.
dc.identifier.issn2296-2360
dc.identifier.urihttp://hdl.handle.net/11351/6872
dc.descriptionGrowth hormone; Metabolism; Russell–Silver syndrome
dc.description.abstractChildren born small for gestational age (SGA) comprise a heterogeneous group due to the varied nature of the cause. Approximately 85-90% have catch-up growth within the first 4 postnatal years, while the remainder remain short. In later life, children born SGA have an increased risk to develop metabolic abnormalities, including visceral adiposity, insulin resistance, and cardiovascular problems, and may have impaired pubertal onset and growth. The third "360° European Meeting on Growth and Endocrine Disorders" in Rome, Italy, in February 2018, funded by Merck KGaA, Germany, included a session that examined aspects of short children born SGA, with three presentations followed by a discussion period, on which this report is based. Children born SGA who remain short are eligible for GH treatment, which is an approved indication. GH treatment increases linear growth and can also improve some metabolic abnormalities. After stopping GH at near-adult height, metabolic parameters normalize, but pharmacological effects on lean body mass and fat mass are lost; continued monitoring of body composition and metabolic changes may be necessary. Guidelines have been published on diagnosis and management of children with Silver-Russell syndrome, who comprise a specific group of those born SGA; these children rarely have catch-up growth and GH treatment initiation as early as possible is recommended. Early and moderate pubertal growth spurt can occur in children born SGA, including those with Silver-Russell syndrome, and reduce adult height. Treatments that delay puberty, specifically metformin and gonadotropin releasing hormone analogs in combination with GH, have been proposed, but are used off-label, currently lack replication of data, and require further studies of efficacy and safety.
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Pediatrics;9
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectSomatotropina
dc.subjectEstatura baixa
dc.subjectMetabolisme - Trastorns
dc.subject.meshGrowth Hormone
dc.subject.meshMetabolic Diseases
dc.subject.meshChild
dc.titleNew Horizons in Short Children Born Small for Gestational Age
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3389/fped.2021.655931
dc.subject.decshormona del crecimiento
dc.subject.decsenfermedades metabólicas
dc.subject.decsniño
dc.relation.publishversionhttps://doi.org/10.3389/fped.2021.655931
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.event.productorBiblioteca
dc.contributor.authoraffiliation[Netchine I] Sorbonne Université, INSERM, UMR_S938 Centre de Recherche Saint Antoine, APHP, Hôpital Armand Trousseau, Explorations Fonctionnelles Endocriniennes, Paris, France. [van der Steen M] Department of Paediatrics, Subdivision of Endocrinology, Erasmus University Medical Centre, Rotterdam, Netherlands. [López-Bermejo A] Institut d’Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. Hospital Universitari de Girona Dr. Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. [Koledova E] Global Medical Affairs Department, Merck KGaA, Darmstadt, Germany. [Maghnie M] Department of Pediatrics, Institute for Research, Hospitalization and Health Care (IRCCS) Children's Hospital Giannina Gaslini, Genova, Italy. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health, University of Genova, Genova, Italy
dc.identifier.pmid34055692
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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