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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRadonjić, Nevena V.
dc.contributor.authorHess, Jonathan L.
dc.contributor.authorRovira Lorente, Paula
dc.contributor.authorAndreassen, Ole
dc.contributor.authorBuitelaar, Jan K.
dc.contributor.authorChing, Christopher R. K.
dc.date.accessioned2022-01-24T13:38:04Z
dc.date.available2022-01-24T13:38:04Z
dc.date.issued2021-06
dc.identifier.citationRadonjić NV, Hess JL, Rovira P, Andreassen O, Buitelaar JK, Ching CRK, et al. Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders. Mol Psychiatry. 2021 Jun;26:2101–2110.
dc.identifier.issn1476-5578
dc.identifier.urihttp://hdl.handle.net/11351/6875
dc.descriptionDiseases; Genetics
dc.description.abstractGenomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, we acquired standardized mean differences (SMDs) in regional brain volume and cortical thickness between cases and controls. We had data on 41 brain regions for: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), epilepsy, major depressive disorder (MDD), obsessive compulsive disorder (OCD), and schizophrenia (SCZ). These data had been derived from 24,360 patients and 37,425 controls. The SMDs were significantly correlated between SCZ and BD, OCD, MDD, and ASD. MDD was positively correlated with BD and OCD. BD was positively correlated with OCD and negatively correlated with ADHD. These pairwise correlations among disorders were correlated with the corresponding pairwise correlations among disorders derived from genomewide association studies (r = 0.494). Our results show substantial similarities in sMRI phenotypes among neuropsychiatric disorders and suggest that these similarities are accounted for, in part, by corresponding similarities in common genetic variant architectures.
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofseriesMolecular Psychiatry;26
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCervell - Imatgeria
dc.subjectMalalties mentals - Aspectes genètics
dc.subject.meshBrain
dc.subject.mesh/diagnostic imaging
dc.subject.meshMental Disorders
dc.subject.mesh/genetics
dc.titleStructural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41380-020-01002-z
dc.subject.decsencéfalo
dc.subject.decs/diagnóstico por imagen
dc.subject.decstrastornos mentales
dc.subject.decs/genética
dc.relation.publishversionhttps://doi.org/10.1038/s41380-020-01002-z
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Radonjić NV] Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA. [Hess JL] Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. [Rovira P] Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Andreassen O] NORMENT—Institute of Clinical Medicine, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway. [Buitelaar JK] Radboudumc, Radboud University Medical Center, Nijmegen, The Netherlands. Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Cognitive Neuroscience, Radboud. [Ching CRK] Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina Del Rey, CA, USA
dc.identifier.pmid33456050
dc.identifier.wos000608389600002
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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