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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorPerea, Jose
dc.contributor.authorMartí Gallostra, Marc
dc.contributor.authorEspin-Basany, Eloy
dc.contributor.authorHernandez-Villafranca, Sergio
dc.contributor.authorOrihuela, Pilar
dc.contributor.authorVidal Tocino, Rosario
dc.date.accessioned2022-01-28T07:24:32Z
dc.date.available2022-01-28T07:24:32Z
dc.date.issued2021-12-30
dc.identifier.citationPerea J, Marti M, Espin E, Hernandez-Villafranca S, Orihuela P, Vidal Tocino R, et al. Cohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain. BMJ Open. 2021 Dec 30;11:e055409.
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/11351/6923
dc.descriptionColorectal cancer; Molecular basis
dc.description.abstractPurpose The Spanish Early-onset Colorectal Cancer (SECOC) study is a multicentre prospective cohort established in Spain to investigate the molecular basis of early-onset colorectal cancer (EOCRC), including metabolic alterations. Participants 220 patients with EOCRC have been enrolled since January 2019 through 18 centres across Spain. Individual-level data were collected by questionnaire, including lifestyle and other colorectal cancer-related factors. Medical record review was performed to capture clinical, histopathological and familial cancer history data. Biospecimen collection (blood, stool, tissue) at diagnosis and at various time points across treatment, as applicable, is also completed. Findings to date Participants had a median age of 44 years (range 14–49), and the majority are men (60%), with individuals age 40–49 years at EOCRC diagnosis being over-represented. Forty-three per cent of participants were diagnosed with a tumour in the rectosigmoid junction/rectum. Nearly two-thirds of EOCRC cases (64%) were diagnosed with advanced stage (III–IV) disease, and 28% of cases had no reported familial history of cancer. Future plans We are actively recruiting and observing participants; we plan to administer follow-up questionnaires and perform additional biospecimen collection. This prospective cohort offers a unique, rich resource for research on EOCRC aetiologies and will contribute to larger international efforts to disentangle the rising disease burden.
dc.language.isoeng
dc.publisherBMJ
dc.relation.ispartofseriesBMJ Open;11
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectQüestionaris
dc.subjectCòlon - Càncer - Espanya - Etiologia
dc.subjectRecte - Càncer - Espanya - Etiologia
dc.subject.meshColorectal Neoplasms
dc.subject.mesh/etiology
dc.subject.meshSurveys and Questionnaires
dc.titleCohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1136/bmjopen-2021-055409
dc.subject.decsneoplasias colorrectales
dc.subject.decs/etiología
dc.subject.decsencuestas y cuestionarios
dc.relation.publishversionhttp://dx.doi.org/10.1136/bmjopen-2021-055409
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Perea J, Hernandez-Villafranca S, Orihuela P] Surgery Department, Fundacion Jimenez Diaz-UTE, Madrid, Spain. [Marti M, Espin E] Servei de Cirurgia General, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Vidal Tocino R] Oncology Department, University Hospital of Salamanca, Salamanca, Castilla y León, Spain
dc.identifier.wos000737300500038
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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