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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorVillanueva-Bueno, Cristina
dc.contributor.authorMontecatine-Alonso, Elena
dc.contributor.authorJiménez-Parrilla, Francisco
dc.contributor.authorFernández-Llamazares, Cecilia M.
dc.contributor.authorManrique-Rodríguez, Silvia
dc.contributor.authorZamora-Flores, Elena
dc.contributor.authorFernandez Polo, Aurora
dc.contributor.authorCastillo Salinas, Félix
dc.contributor.authorComuñas Gómez, Juan José
dc.date.accessioned2022-02-21T09:50:06Z
dc.date.available2022-02-21T09:50:06Z
dc.date.issued2022-02
dc.identifier.citationVillanueva-Bueno C, Montecatine-Alonso E, Jiménez-Parrilla F, Fernández-Llamazares CM, Manrique-Rodríguez S, Zamora-Flores E, et al. Antimicrobial defined daily dose in neonatal population. Enferm Infecc Microbiol Clin. 2022 Feb;40(2):59–65.
dc.identifier.issn0213-005X
dc.identifier.urihttp://hdl.handle.net/11351/7045
dc.descriptionAntimicrobial consumption; Neonatal antimicrobial prescription; Neonatology
dc.description.abstractBackground Antimicrobial defined daily dose (DDD), a standardized metric to assess antimicrobial consumption in adult population, has limitations hampering its use in neonatal patients. This study proposes an alternative DDD design applicable for neonates. Methods Neonates (<1 month-old) from 6 Spanish hospitals during a 12-months period were included. Weight and weeks gestational age of each neonate were the variables collected. DDD (g) for each antimicrobial was calculated by multiplying the obtained weight times the recommended dose (mg/kg) of the antimicrobial for the most common infectious indication selected by the Delphi method. Results A total of 4820 neonates were included. Mean age was 36.72 weeks of gestational age and Mean weight was 2.687 kg. Standardized DDD (intravenous; oral route) for representative antimicrobials were: Amoxicillin (0.08; 0.08), amoxicillin-clavulanic acid (0.27; 0.08), ampicillin (0.27; x), cloxacillin (0.13; 0.13), penicillin G sodium (0.12), cefazolin (0.13), cefuroxime (0.27; x), cefotaxime (0.27), ceftazidime (0.27), ceftriaxone (0.13), cefepime (0.27) piperacillin-tazobactam (0.54), aztreonam (0.24), azithromycin (0.03; 0.03), clindamycin (0.04; 0.04), amikacin (0.04), gentamicin (0.01), metronidazole (0.04; 0.08), ciprofloxacin (0.04; 0.05), levofloxacin (x;x), fluconazole (0.02; 0.02), itraconazole (0.01; 0.01), fosfomycin (0.27). Restricted antimicrobials: meropenem (0.11), teicoplanin (0.02), vancomycin (0.08; 0.11), linezolid (0.08; 0.08), daptomycin (x), amphotericin B liposomal (0.01). Conclusions A useful method for antimicrobial DDD measurement in neonatology has been designed to monitor antimicrobial consumption in hospital settings. It should be validated in further studies and thereby included in the design for neonatal antimicrobial stewardship programs in the future.
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesEnfermedades Infecciosas y Microbiología Clínica;40(2)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectInfants nadons
dc.subjectPosologia
dc.subjectMedicaments antiinfecciosos
dc.subject.meshDrug Dosage Calculations
dc.subject.meshInfant, Newborn
dc.subject.meshAnti-Infective Agents
dc.subject.mesh/administration & dosage
dc.titleAntimicrobial defined daily dose in neonatal population
dc.title.alternativeDosis diaria definida de antimicrobianos en la población neonatal
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.eimc.2021.05.007
dc.subject.decscálculos de dosificación de medicamentos
dc.subject.decsrecién nacido
dc.subject.decsantiinfecciosos
dc.subject.decs/administración & dosificación
dc.relation.publishversionhttps://doi.org/10.1016/j.eimc.2021.05.007
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Villanueva-Bueno C, Montecatine-Alonso E] Department of Pharmacy, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Jiménez-Parrilla F] Department of Neonatology, Hospital Universitario Virgen del Rocío, Seville, Spain. [Fernández-Llamazares CM, Manrique-Rodríguez S] Department of Pharmacy, Hospital Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Research Network on Maternal and Child Health and Development II (Red SAMID II), Spanish Health Institute Carlos III, Madrid, Spain. [Zamora-Flores E] Neonatology Division, Department of Pediatrics, Gregorio Marañon Biomedical Research Institute, Gregorio Marañon University Hospital, Complutense University, Madrid, Spain. [Fernández-Polo A] Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. PROA-NEN Project, Barcelona, Spain. [Catillo-Salinas F, Comuñas J] Servei de Neonatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid34183175
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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