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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorJacobs Cachá, Concepció
dc.contributor.authorVergara Arana, Ander
dc.contributor.authorGarcía Carro, Clara
dc.contributor.authorAgraz Pamplona, Irene
dc.contributor.authorToapanta Gaibor, Nestor Gabriel
dc.contributor.authorMoreso Mateos, Francesc
dc.contributor.authorSerón Micas, Daniel
dc.contributor.authorLópez Hellin, Joan
dc.contributor.authorSoler Romeo, Maria Jose
dc.contributor.authorAriceta Iraola, Gema
dc.date.accessioned2022-02-22T07:13:21Z
dc.date.available2022-02-22T07:13:21Z
dc.date.copyright2020
dc.date.issued2021-02
dc.identifier.citationJacobs-Cachá C, Vergara A, García-Carro C, Agraz I, Toapanta-Gaibor N, Ariceta G, et al. Challenges in primary focal segmental glomerulosclerosis diagnosis: from the diagnostic algorithm to novel biomarkers. Clin Kidney J. 2021 Feb 16;14(2):482–91.
dc.identifier.issn2048-8513
dc.identifier.urihttps://hdl.handle.net/11351/7048
dc.descriptionBiomarkers; Diagnosis algorithm; Focal segmental glomerulosclerosis
dc.description.abstractPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) is a kidney entity that involves the podocytes, leading to heavy proteinuria and in many cases progresses to end-stage renal disease. Idiopathic FSGS has a bad prognosis, as it involves young individuals who, in a considerably high proportion (∼15%), are resistant to corticosteroids and other immunosuppressive treatments as well. Moreover, the disease recurs in 30–50% of patients after kidney transplantation, leading to graft function impairment. It is suspected that this relapsing disease is caused by a circulating factor(s) that would permeabilize the glomerular filtration barrier. However, the exact pathologic mechanism is an unsettled issue. Besides its poor outcome, a major concern of primary FSGS is the complexity to confirm the diagnosis, as it can be confused with other variants or secondary forms of FSGS and also with other glomerular diseases, such as minimal change disease. New efforts to optimize the diagnostic approach are arising to improve knowledge in well-defined primary FSGS cohorts of patients. Follow-up of properly classified primary FSGS patients will allow risk stratification for predicting the response to different treatments. In this review we will focus on the diagnostic algorithm used in idiopathic FSGS both in native kidneys and in disease recurrence after kidney transplantation. We will emphasize those potential confusing factors as well as their detection and prevention. In addition, we will also provide an overview of ongoing studies that recruit large cohorts of glomerulopathy patients (Nephrotic Syndrome Study Network and Cure Glomerulonephropathy, among others) and the experimental studies performed to find novel reliable biomarkers to detect primary FSGS.
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofseriesClinical Kidney Journal;14(2)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectRonyons - Malalties - Diagnòstic
dc.subjectRonyons - Trasplantació - Complicacions
dc.subjectRonyons - Malalties - Tractament
dc.subject.meshKidney Diseases
dc.subject.mesh/therapy
dc.subject.meshKidney Transplantation
dc.subject.mesh/adverse effects
dc.titleChallenges in primary focal segmental glomerulosclerosis diagnosis: from the diagnostic algorithm to novel biomarkers
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1093/ckj/sfaa110
dc.subject.decsenfermedades renales
dc.subject.decs/terapia
dc.subject.decstrasplante de riñón
dc.subject.decs/efectos adversos
dc.relation.publishversionhttps://doi.org/10.1093/ckj/sfaa110
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Jacobs-Cachá C, García-Carro C, Agraz I, Moreso F, Serón D, Soler MJ] Grup de Recerca en Nefrologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Vergara A, Toapanta-Gaibor N] Grup de Recerca en Nefrologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ariceta G] Red de Investigaciones Renales (RedInRen), Madrid, Spain. Servei de Nefrologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [López-Hellín J] Red de Investigaciones Renales (RedInRen), Madrid, Spain. Servei de Bioquímica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Recerca en Bioquímica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
dc.identifier.pmid33623672
dc.identifier.wos000642298900005
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F01704
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F01832
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0009%2F0030
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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