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dc.contributorHospital Universitari de Girona Dr Josep Trueta
dc.contributor.authorVera, Manel
dc.contributor.authorCheak, Bee Boon
dc.contributor.authorChmelíčková, Hana
dc.contributor.authorBavanandan, Sunita
dc.contributor.authorGoh, Bak Leong
dc.contributor.authorAbdul Gafor, Abdul Halim
dc.contributor.authorGarcía-Méndez, Isabel
dc.date.accessioned2022-03-04T07:53:09Z
dc.date.available2022-03-04T07:53:09Z
dc.date.issued2021-12-09
dc.identifier.citationVera M, Cheak BB, Chmelíčková H, Bavanandan S, Goh BL, Abdul Gafor AH, et al. Current clinical practice in adapted automated peritoneal dialysis (aAPD)-A prospective, non-interventional study. PLoS One. 2021 Dec 9;16(12):e0258440.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11351/7115
dc.descriptionChronic Kidney Failure; Peritoneal Dialysis
dc.description.abstractAdapted automated peritoneal dialysis (aAPD), comprising a sequence of dwells with different durations and fill volumes, has been shown to enhance both ultrafiltration and solute clearance compared to standard peritoneal dialysis with constant time and volume dwells. The aim of this non-interventional study was to describe the different prescription patterns used in aAPD in clinical practice and to observe outcomes characterizing volume status, dialysis efficiency, and residual renal function over 1 year. Prevalent and incident, adult aAPD patients were recruited during routine clinic visits, and aAPD prescription, volume status, residual renal function and laboratory data were documented at baseline and every quarter thereafter for 1 year. Treatments were prescribed according to the nephrologist's medical judgement in accordance with each center's clinical routine. Of 180 recruited patients, 160 were analyzed. 27 different aAPD prescription patterns were identified. 79 patients (49.4%) received 2 small, short dwells followed by 3 long, large dwells. During follow-up, volume status changed only marginally, with visit mean values ranging between 1.59 (95% confidence interval: 1.19; 1.99) and 1.97 (1.33; 2.61) L. Urine output and creatinine clearance decreased significantly, accompanied by reductions in ultrafiltration and Kt/V. 25 patients (15.6%) received a renal transplant and 15 (9.4%) were changed to hemodialysis. Options for individualization offered by aAPD are actually used in practice for optimized treatment. Changes observed in renal function and dialysis efficiency measures reflect the natural course of chronic kidney disease. No safety events were observed during the study period.
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.ispartofseriesPloS one;16(12)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectInsuficiència renal crònica
dc.subjectDiàlisi peritoneal
dc.subject.meshKidney Failure, Chronic
dc.subject.meshPeritoneal Dialysis
dc.subject.meshProspective Studies
dc.titleCurrent clinical practice in adapted automated peritoneal dialysis (aAPD)-A prospective, non-interventional study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1371/journal.pone.0258440
dc.subject.decsfallo renal crónico
dc.subject.decsdiálisis peritoneal
dc.subject.decsestudios prospectivos
dc.relation.publishversionhttps://doi.org/10.1371/journal.pone.0258440
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Vera M] Nephrology, Hospital Clinic de Barcelona, Barcelona, Spain. [Cheak BB] Department of Nephrology, Hospital Selayang, Selangor, Malaysia. [Chmelíčková H] Nephrology, Hospital Trebic, Trebic, Czech Republic. [Bavanandan S] Nephrology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia. [Goh BL] Nephrology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia. [Abdul Gafor AH] Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. [García I] Departament de Nefrologia, Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain
dc.identifier.pmid34882678
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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