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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorPinteac, Rucsanda
dc.contributor.authorMontalban Gairín, Xavier
dc.contributor.authorComabella Lopez, Manuel
dc.date.accessioned2022-03-14T12:34:17Z
dc.date.available2022-03-14T12:34:17Z
dc.date.copyright2020
dc.date.issued2021-01
dc.identifier.citationPinteac R, Montalban X, Comabella M. Chitinases and chitinase-like proteins as biomarkers in neurologic disorders. Neurol Neuroimmunol Neuroinflamm. 2021 Jan;8(1):e921.
dc.identifier.issn2332-7812
dc.identifier.urihttp://hdl.handle.net/11351/7158
dc.descriptionMultiple sclerosis; Alzheimer's disease; Amyotrophic lateral sclerosis
dc.description.abstractChitinases are hydrolytic enzymes widely distributed in nature. Despite their physiologic and pathophysiologic roles are not well understood, chitinases are emerging as biomarkers in a broad range of neurologic disorders, where in many cases, protein levels measured in the CSF have been shown to correlate with disease activity and progression. In this review, we will summarize the structural features of human chitinases and chitinase-like proteins and their potential physiologic and pathologic functions in the CNS. We will also review existing evidence for the role of chitinases and chitinase-like proteins as diagnostic and prognostic biomarkers in inflammatory, neurodegenerative diseases, and psychiatric disorders. Finally, we will comment on future perspectives of chitinase studies in neurologic conditions.
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofseriesNeurology-Neuroimmunology & Neuroinflammation;8(1)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectSistema nerviós - Malalties - Tractament
dc.subjectEnzims - Metabolisme
dc.subject.meshNervous System Diseases
dc.subject.mesh/enzymology
dc.subject.meshChitinases
dc.subject.mesh/metabolism
dc.titleChitinases and chitinase-like proteins as biomarkers in neurologic disorders
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1212/NXI.0000000000000921
dc.subject.decsenfermedades del sistema nervioso
dc.subject.decs/enzimología
dc.subject.decsquitinasas
dc.subject.decs/metabolismo
dc.relation.publishversionhttps://doi.org/10.1212/NXI.0000000000000921
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Pinteac R, Comabella M] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Montalban X] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid33293459
dc.identifier.wos000611846700018
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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