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dc.contributorHospital General de Granollers
dc.contributor.authorBadia, Josep M
dc.contributor.authorFlores Yélamos, Míriam
dc.contributor.authorVázquez, Ana
dc.contributor.authorArroyo García, Nares
dc.contributor.authorPuig Asensio, Mireia
dc.contributor.authorParés, David
dc.contributor.authorPera, Miguel
dc.contributor.authorLopez-Contreras, Joaquin
dc.contributor.authorLimón, Enric
dc.contributor.authorPujol, Miquel
dc.date.accessioned2022-03-16T12:26:12Z
dc.date.available2022-03-16T12:26:12Z
dc.date.issued2021-11-29
dc.identifier.citationBadia JM, Flores-Yelamos M, Vázquez A, Arroyo-García N, Puig-Asensio M, Parés D, et al. Oral Antibiotic Prophylaxis Lowers Surgical Site Infection in Elective Colorectal Surgery: Results of a Pragmatic Cohort Study in Catalonia. J Clin Med. 2021 Nov 29;10(23):5636.
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/11351/7190
dc.descriptionColorectal surgery; Mechanical bowel preparation; Oral antibiotic prophylaxis
dc.description.abstractBackground: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infection Surveillance Network in Catalonia. Methods: Pragmatic cohort study to assess the effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline phase (BP: 2007-2015) with implementation phase (IP: 2016-2019). To compare the results, a logistic regression model was established. Results: Out of 34,421 colorectal operations, 5180 had SSIs (15.05%). Overall SSI rate decreased from 18.81% to 11.10% in BP and IP, respectively (OR 0.539, CI95 0.507-0.573, p < 0.0001). Information about bundle implementation was complete in 61.7% of cases. In a univariate analysis, OAP and MBP were independent factors in decreasing overall SSI, with OR 0.555, CI95 0.483-0.638, and OR 0.686, CI95 0.589-0.798, respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0.592, CI95 0.494-0.710, and OR 0.771, CI95 0.630-0.944, respectively). However, only OAP retained its protective effect at both levels at multivariate analyses. Conclusions: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI in a large series of elective colorectal surgery.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesJournal of Clinical Medicine;10(23)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectInfecció
dc.subjectAntibiòtics
dc.subjectCòlon - Cirurgia
dc.subject.meshColorectal Surgery
dc.subject.meshSurgical Wound Infection
dc.subject.meshAntibiotic Prophylaxis
dc.titleOral Antibiotic Prophylaxis Lowers Surgical Site Infection in Elective Colorectal Surgery: Results of a Pragmatic Cohort Study in Catalonia
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/jcm10235636
dc.subject.decscirugía colorrectal
dc.subject.decsinfección de la herida quirúrgica
dc.subject.decsprofilaxis antibiótica
dc.relation.publishversionhttps://doi.org/10.3390/jcm10235636
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.aplicacio.aplicacio
dc.contributor.authoraffiliation[Badia JM, Flores-Yelamos M, Arroyo-García N] Department of Surgery, Hospital General Granollers, Granollers, Spain. School of Medicine, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Barcelona, Spain. [Vázquez A] Servei d’Estadística Aplicada, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. [Puig-Asensio M] Department of Infectious Diseases, Hospital Universitari de Bellvitge, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0005), L’Hospitalet del Llobregat, Spain. [Parés D] Department of Surgery, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. [Pera M] Department of Surgery, Hospital del Mar, Barcelona, Spain. [López-Contreras J] Infectious Disease Unit, Hospital de la Santa Creu i Sant Pau–Institut d’Investigació Biomèdica Sant Pau, Barcelona, Spain. [Limón E] VINCat Program, Barcelona, Spain. Universitat de Barcelona, Barcelona, Spain. [Pujol M] Department of Infectious Diseases, Hospital Universitari de Bellvitge, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0005), L’Hospitalet del Llobregat, Spain. VINCat Program, Barcelona, Spain
dc.identifier.pmid34884337
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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