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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBertozzi, Ana Paula Antunes Pascalicchio
dc.contributor.authorGazeta, Rosa Estela
dc.contributor.authorFajardo, Thamirys Cosmo Gillo
dc.contributor.authorMoron, Antonio Fernandes
dc.contributor.authorSoriano Arandes, Antoni
dc.contributor.authorAlarcon, Ana
dc.date.accessioned2022-03-22T14:26:16Z
dc.date.available2022-03-22T14:26:16Z
dc.date.issued2021-07
dc.identifier.citationBertozzi APAP, Gazeta RE, Fajardo TCG, Moron AF, Soriano-Arandes A, Alarcon A, et al. Prevalence and diagnostic accuracy of microcephaly in a pediatric cohort in Brazil: a retrospective cross-sectional study. J Pediatr (Rio J). 2021 Jul;97(4):433–9.
dc.identifier.issn0021-7557
dc.identifier.urihttp://hdl.handle.net/11351/7239
dc.descriptionCongenital abnormalities; Epidemiology; Microcephaly
dc.description.abstractObjective We sought to describe the prevalence of microcephaly and to compare the different cutoff points established by the Brazilian Ministry of Health at various times during a Zika virus epidemic. As a secondary aim, we investigated the possible etiology of the microcephaly. Method This retrospective study utilized newborn participants in the Zika Cohort Study Jundiaí. Newborns from the Zika Cohort Study Jundiaí with an accurate gestational age determination and complete anthropometric data were analyzed, and microcephaly was diagnosed according to the INTERGROWTH-21st curve. At delivery, fluids were tested for specific antibodies and for viruses. Brain images were evaluated for microcephaly. Receiver Operating Characteristic curves were plotted to define the accuracy of different cutoff points for microcephaly diagnosis. Results Of 462 eligible newborns, 19 (4.1%) were positive for microcephaly. Cutoff points corresponding to the curves of the World Health Organization yielded the best sensitivity and specificity. Three of the microcephaly cases (15.8%) were positive for Zika virus infections; nine (47.4%) had intrauterine growth restriction; one had intrauterine growth restriction and was exposed to Zika virus; three had a genetic syndrome (15.8%); and three had causes that had not been determined (15.8%). Conclusions Microcephaly prevalence was 4.1% in this study. Cutoff values determined by the World Health Organization had the highest sensitivity and specificity in relation to the standard IG curve. The main reason for microcephaly was intrauterine growth restriction. All possible causes of microcephaly must be investigated to allow the best development of an affected baby.
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesJornal de Pediatria;97(4)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectCervell - Malalties - Diagnòstic - Brasil
dc.subjectArbovirosis - Brasil
dc.subject.meshMicrocephaly
dc.subject.mesh/diagnosis
dc.subject.meshZika Virus Infection
dc.subject.meshBrazil
dc.titlePrevalence and diagnostic accuracy of microcephaly in a pediatric cohort in Brazil: a retrospective cross-sectional study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.jped.2020.08.010
dc.subject.decsmicrocefalia
dc.subject.decs/diagnóstico
dc.subject.decsinfección por el virus del Zika
dc.subject.decsBrasil
dc.relation.publishversionhttps://doi.org/10.1016/j.jped.2020.08.010
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Bertozzi APAP, Gazeta RE] Faculdade de Medicina de Jundiaí, Departamento de Pediatria, Jundiaí, SP, Brazil. [Fajardo TCG] Faculdade de Medicina de Jundiaí, Laboratório de Infectologia Pediátrica, Jundiaí, SP, Brazil. [Moron AF] Universidade de São Paulo (USP), Instituto de Medicina Tropical, São Paulo, SP, Brazil. [Soriano-Arandes A] Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Unitat de Salut Internacional-Tuberculosi, Vall Hebron Hospital Universitari - Drassanes, Barcelona, Spain. [Alarcon A] Hospital Universitari Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Department of Neonatology, Esplugues de Llobregat, Spain
dc.identifier.pmid33086050
dc.identifier.wos000691756100012
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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