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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRamon-Krauel, Marta
dc.contributor.authorLeal-Witt, María Jesús
dc.contributor.authorOsorio-Conles, Óscar
dc.contributor.authorAmat-Bou, Montse
dc.contributor.authorLerin, Carles
dc.contributor.authorMartinez Selva, David
dc.date.accessioned2022-04-06T12:52:23Z
dc.date.available2022-04-06T12:52:23Z
dc.date.issued2021-03-10
dc.identifier.citationRamon-Krauel M, Leal-Witt MJ, Osorio-Conles O, Amat-Bou M, Lerin C, Selva DM. Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity. Mol Cell Pediatr. 2021 Mar 10;8:3.
dc.identifier.issn2194-7791
dc.identifier.urihttp://hdl.handle.net/11351/7322
dc.descriptionCytokines; Obesity; Prepubertal children
dc.description.abstractBackground Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production. Aim The main objective of this study was to assess if the adult associations between TNFα, adiponectin, and SHBG are present in prepubertal children. Methods We determined several morphometric and biochemical parameters in normal-weight (n=15) and obese prepubertal (n=51) children, as well as quantified plasma SHBG, TNFα receptor 1 (TNFα-R1), and adiponectin levels. Results Our results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/L vs 172 nmol/L). Importantly, SHBG plasma levels correlated significantly (P < 0.05) with TNFα (negatively, ßstd= − 0.31) and adiponectin (positively, ßstd= 0.58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children. Conclusions Our results suggest that plasma adiponectin levels may play a more important role than TNFα in influencing plasma SHBG levels in our prepubertal population with obesity.
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofseriesMolecular and Cellular Pediatric;8
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectObesitat
dc.subjectHormones sexuals - Metabolisme
dc.subjectPubertat
dc.subject.meshSex Hormone-Binding Globulin
dc.subject.mesh/metabolism
dc.subject.meshAdiponectin
dc.subject.meshObesity
dc.titleRelationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s40348-021-00113-z
dc.subject.decsglobulina de unión a hormonas sexuales
dc.subject.decs/metabolismo
dc.subject.decsadiponectina
dc.subject.decsobesidad
dc.relation.publishversionhttps://doi.org/10.1186/s40348-021-00113-z
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Ramon-Krauel M, Leal-Witt MJ, Osorio-Conles O, Amat-Bou M, Lerin C] Endocrinology Department, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08950 Barcelona, Spain. [Selva DM] Unitat de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid33689083
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI12%2F01357
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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