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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorLasheras Márquez, Jaime
dc.contributor.authorPardo Diaz, Rosario
dc.contributor.authorVelilla Cajo, Marc
dc.contributor.authorPoncelas Nozal, Marcos
dc.contributor.authorSalvatella Serrallonga, Nuria
dc.contributor.authorSimó Canonge, Rafael
dc.contributor.authorRuiz Meana, Marisol
dc.contributor.authorVillena Delgado, Josep A
dc.date.accessioned2022-04-11T10:26:03Z
dc.date.available2022-04-11T10:26:03Z
dc.date.issued2021-08
dc.identifier.citationLasheras J, Pardo R, Velilla M, Poncelas M, Salvatella N, Simó R, et al. Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality. Int J Mol Sci. 2021 Aug;22(15):8047.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11351/7344
dc.descriptionCardiac dysfunction; Estrogen-related receptors; Transgenic mice
dc.description.abstractProper cardiac function depends on the coordinated expression of multiple gene networks related to fuel utilization and mitochondrial ATP production, heart contraction, and ion transport. Key transcriptional regulators that regulate these gene networks have been identified. Among them, estrogen-related receptors (ERRs) have emerged as crucial modulators of cardiac function by regulating cellular metabolism and contraction machinery. Consistent with this role, lack of ERRα or ERRγ results in cardiac derangements that lead to functional maladaptation in response to increased workload. Interestingly, metabolic inflexibility associated with diabetic cardiomyopathy has been recently associated with increased mitochondrial fatty acid oxidation and expression of ERRγ, suggesting that sustained expression of this nuclear receptor could result in a cardiac pathogenic outcome. Here, we describe the generation of mice with cardiac-specific overexpression of ERRγ, which die at young ages due to heart failure. ERRγ transgenic mice show signs of dilated cardiomyopathy associated with cardiomyocyte hypertrophy, increased cell death, and fibrosis. Our results suggest that ERRγ could play a role in mediating cardiac pathogenic responses.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesInternational Journal of Molecular Sciences;22(15)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCor - Metabolisme
dc.subjectMiocardi - Malalties - Metabolisme
dc.subject.meshMyocytes, Cardiac
dc.subject.meshCardiomyopathy, Dilated
dc.subject.mesh/metabolism
dc.titleCardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/ijms22158047
dc.subject.decsmiocitos cardíacos
dc.subject.decsmiocardiopatía dilatada
dc.subject.decs/metabolismo
dc.relation.publishversionhttps://doi.org/10.3390/ijms22158047
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Lasheras J, Pardo R, Velilla M, Salvatella N] Laboratori de Metabolisme i Obesitat, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Poncelas M, Ruiz-Meana M] Laboratori de Cardiologia Experimental, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Simó R] Unitat de Diabetis i Metabolisme, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain. [Villena JA] Laboratori de Metabolisme i Obesitat, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain
dc.identifier.pmid34360813
dc.identifier.wos000681968700001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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