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dc.contributorHospital General de Granollers
dc.contributor.authorWendel Garcia, Pedro David
dc.contributor.authorMas Serra, Arantxa
dc.contributor.authorGonzález‑Isern, Cristina
dc.contributor.authorFerrer Roca, Ricard
dc.contributor.authorMáñez, Rafael
dc.contributor.authorMasclans, Joan R.
dc.contributor.authorGarro, Pau
dc.date.accessioned2022-04-13T10:31:48Z
dc.date.available2022-04-13T10:31:48Z
dc.date.issued2022-02-08
dc.identifier.citationWendel-Garcia PD, Mas A, González-Isern C, Ferrer R, Máñez R, Masclans JR, et al. Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study. Crit Care. 2022 Feb 8;26(1):37.
dc.identifier.urihttp://hdl.handle.net/11351/7368
dc.descriptionAcute hypoxemic respiratory failure; COVID-19; Intensive care
dc.description.abstractBackground: Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during the coronavirus disease 2019 (COVID-19). While the efficacy of these therapies has been studied in hospitalized patients with COVID-19, the clinical outcomes associated with oxygen masks, high-flow oxygen therapy by nasal cannula and non-invasive mechanical ventilation in critically ill intensive care unit (ICU) patients remain unclear. Methods: In this retrospective study, we used the best of nine covariate balancing algorithms on all baseline covariates in critically ill COVID-19 patients supported with > 10 L of supplemental oxygen at one of the 26 participating ICUs in Catalonia, Spain, between March 14 and April 15, 2020. Results: Of the 1093 non-invasively oxygenated patients at ICU admission treated with one of the three stand-alone non-invasive oxygenation strategies, 897 (82%) required endotracheal intubation and 310 (28%) died during the ICU stay. High-flow oxygen therapy by nasal cannula (n = 439) and non-invasive mechanical ventilation (n = 101) were associated with a lower rate of endotracheal intubation (70% and 88%, respectively) than oxygen masks (n = 553 and 91% intubated), p < 0.001. Compared to oxygen masks, high-flow oxygen therapy by nasal cannula was associated with lower ICU mortality (hazard ratio 0.75 [95% CI 0.58-0.98), and the hazard ratio for ICU mortality was 1.21 [95% CI 0.80-1.83] for non-invasive mechanical ventilation. Conclusion: In critically ill COVID-19 ICU patients and, in the absence of conclusive data, high-flow oxygen therapy by nasal cannula may be the approach of choice as the primary non-invasive oxygenation support strategy.
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofseriesCritical Care;26(1)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectSíndrome del destret respiratori de l'adult
dc.subjectCOVID-19 (Malaltia)
dc.subjectUnitats de cures intensives
dc.subject.meshSevere Acute Respiratory Syndrome
dc.subject.meshIntensive Care Units
dc.subject.meshCoronavirus Infections
dc.titleNon‑invasive oxygenation support in acutely hypoxemic COVID‑19 patients admitted to the ICU: a multicenter observational retrospective study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s13054-022-03905-5
dc.subject.decssíndrome respiratorio agudo grave
dc.subject.decsunidades de cuidados intensivos
dc.subject.decsinfecciones por Coronavirus
dc.relation.publishversionhttps://doi.org/10.1186/s13054-022-03905-5
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Wendel-Garcia PD] Institute of Intensive Care Medicine, University Hospital of Zurich, Zurich, Switzerland. [Mas A] Intensive Care Department, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Spain. [González-Isern C] Medical Technology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain. [Ferrer R] Intensive Care Department/SODIR Research Group, Hospital Universitari General de La Vall d’Hebron, Barcelona, Spain. [Máñez R] Intensive Care Department, L’Hospitalet de Llobregat, Barcelona, Spain. [Masclans JR] Intensive Care Department, Hospital del Mar, GREPAC Research Group ‑ IMIM, Department Ciències, Experimentals I de La Salut (DCEXS) UPF, Barcelona, Spain. [Garro P] Intensive Care Department, Hospital General de Granollers, Granollers, Spain
dc.identifier.pmid35135588
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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