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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorZapatero, Almudena
dc.contributor.authorMaldonado Pijoan, Javier
dc.contributor.authorGómez‑Caamaño, Antonio
dc.contributor.authorPardo Masferrer, José
dc.contributor.authorMacías Hernández, Víctor
dc.contributor.authorHervás Morón, Asunción
dc.date.accessioned2022-04-25T12:56:33Z
dc.date.available2022-04-25T12:56:33Z
dc.date.issued2021-09-25
dc.identifier.citationZapatero A, Maldonado Pijoan X, Gómez-Caamaño A, Pardo Masferrer J, Macías Hernández V, Hervás Morón A, et al. Health-related quality of life in men with localized prostate cancer treated with radiotherapy: validation of an abbreviated version of the Expanded Prostate Cancer Index Composite for Clinical Practice in Spain. Health Qual Life Outcomes. 2021 Sep 25;19:223.
dc.identifier.issn1477-7525
dc.identifier.urihttp://hdl.handle.net/11351/7394
dc.descriptionProstate cancer; Quality-of-life assessment; Radiotherapy
dc.description.abstractBackground Health-related quality of life (HRQoL) is greatly affected by prostate cancer (PCa) and associated treatments. This study aimed to measure the impact of radiotherapy on HRQoL and to further validate the Spanish version of the 16-item Expanded Prostate Cancer Index Composite (EPIC-16) in routine clinical practice. Methods An observational, non-interventional, multicenter study was conducted in Spain with localized PCa patients initiating treatment with external beam radiotherapy (EBRT) or brachytherapy (BQT). Changes from baseline in EPIC-16, University of California-Los Angeles Prostate Cancer Index (UCLA-PCI), and patient-perceived health status were longitudinally assessed at end of radiotherapy (V2) and 90 days thereafter (V3). Psychometric evaluations of the Spanish EPIC-16 were conducted. Results Of 516 patients enrolled, 495 were included in the analysis (EBRT, n = 361; BQT, n = 134). At baseline, mean (standard deviation [SD]) EPIC-16 global scores were 11.9 (7.5) and 10.3 (7.7) for EBRT and BQT patients, respectively; scores increased, i.e., HRQoL worsened, from baseline, by mean (SD) of 6.8 (7.6) at V2 and 2.4 (7.4) at V3 for EBRT and 4.2 (7.6) and 3.9 (8.2) for BQT patients. Changes in Spanish EPIC-16 domains correlated well with urinary, bowel, and sexual UCLA-PCI domains. EPIC-16 showed good internal consistency (Cronbach’s alpha = .84), reliability, and construct validity. Conclusion The Spanish EPIC-16 questionnaire demonstrated sensitivity, strong discriminative properties and reliability, and validity for use in clinical practice. EPIC-16 scores worsened after radiotherapy in different HRQoL domains; however, a strong tendency towards recovery was seen at the 3-month follow-up visit.
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofseriesHealth and Quality of Life Outcomes;19
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectPròstata - Càncer - Radioteràpia
dc.subjectQüestionaris
dc.subjectAvaluació de resultats (Assistència sanitària)
dc.subject.meshProstatic Neoplasms
dc.subject.mesh/radiotherapy
dc.subject.meshReproducibility of Results
dc.subject.meshSurveys and Questionnaires
dc.titleHealth-related quality of life in men with localized prostate cancer treated with radiotherapy: validation of an abbreviated version of the Expanded Prostate Cancer Index Composite for Clinical Practice in Spain
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s12955-021-01856-z
dc.subject.decsneoplasias de la próstata
dc.subject.decs/radioterapia
dc.subject.decsreproducibilidad de los resultados
dc.subject.decsencuestas y cuestionarios
dc.relation.publishversionhttps://doi.org/10.1186/s12955-021-01856-z
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Zapatero A] Department of Radiation Oncology, Hospital Universitario de La Princesa, Madrid, Spain. [Maldonado Pijoan X] Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Gómez-Caamaño A] Department of Radiation Oncology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. [Pardo Masferrer J] Department of Radiation Oncology, Hospital Universitari Son Espases, Palma de Mallorca, Spain. [Macías Hernández V] Hospital Universitario Y Politecnico La Fe, Valencia, Spain. [Hervás Morón A] Department of Radiation Oncology, Hospital Ramon Y Cajal, Madrid, Spain
dc.identifier.pmid34563208
dc.identifier.wos000699023500002
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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