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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorLensen, Karel-Jan Dag François
dc.contributor.authorEscudero-Sanchez, Rosa
dc.contributor.authorCobo, Javier
dc.contributor.authorTrebše, Rihard
dc.contributor.authorGubavu, Camelia
dc.contributor.authorTedeschi, Sara
dc.contributor.authorRodríguez Pardo, Ma Dolores
dc.date.accessioned2022-04-25T14:56:21Z
dc.date.available2022-04-25T14:56:21Z
dc.date.issued2021-08-17
dc.identifier.citationLensen KDF, Escudero-Sanchez R, Cobo J, Trebše R, Gubavu C, Tedeschi S, et al. The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus. J Bone Jt Infect. 2021 Aug 17;6(7):313–319.
dc.identifier.issn2206-3552
dc.identifier.urihttp://hdl.handle.net/11351/7407
dc.descriptionEfficacy; Antibiotic treatment; Joint infection
dc.description.abstractObjectives: Patients with prosthetic joint infections (PJIs) not suitable for curative surgery may benefit from suppressive antibiotic therapy (SAT). However, the usefulness of SAT in cases with a draining sinus has never been investigated. Methods: A multicentre, retrospective observational cohort study was performed in which patients with a PJI and a sinus tract were eligible for inclusion if managed conservatively and if sufficient follow-up data were available (i.e. at least 2 years). SAT was defined as a period of > 6 months of oral antibiotic therapy. Results: SAT was initiated in 63 of 72 (87.5 %) included patients. Implant retention during follow-up was the same in patients receiving SAT vs. no SAT (79.4 % vs. 88.9 %; p=0.68). In total, 27 % of patients using SAT experienced side effects. In addition, the occurrence of prosthetic loosening in initially fixed implants, the need for surgical debridement, or the occurrence of bacteremia during follow-up could not be fully prevented with the use of SAT, which still occurred in 42 %, 6.3 %, and 3.2 % of cases, respectively. However, the sinus tract tended to close more often (42 % vs. 13 %; p=0.14), and a higher resolution of pain was observed (35 % vs. 14 %; p=0.22) in patients receiving SAT. Conclusions: SAT is not able to fully prevent complications in patients with a draining sinus. However, it may be beneficial in a subset of patients, particularly in those with pain or the hindrance of a draining sinus. A future prospective study, including a higher number of patients not receiving SAT, is needed.
dc.language.isoeng
dc.publisherCopernicus Publications
dc.relation.ispartofseriesJournal of Bone and Joint Infection;6(7)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectAvaluació de resultats (Assistència sanitària)
dc.subjectArticulacions artificials
dc.subjectInfecció
dc.subject.meshProsthesis-Related Infections
dc.subject.mesh/drug therapy
dc.subject.meshTreatment Outcome
dc.titleThe efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.5194/jbji-6-313-2021
dc.subject.decsinfecciones relacionadas con prótesis
dc.subject.decs/farmacoterapia
dc.subject.decsresultado del tratamiento
dc.relation.publishversionhttps://doi.org/10.5194/jbji-6-313-2021
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Lensen KDF] Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [Escudero-Sanchez R, Cobo J] Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain. [Trebše R] Service for Bone Infections, Valdoltra Orthopaedic Hospital, Ankaran, Slovenia. [Gubavu C] Department of Infectious and Tropical Diseases, CHR Orléans, Orléans, France. [Tedeschi S] Infectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna Policlinico di Sant Orsola, Bologna, Italy. [Rodriguez-Pardo D] Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid34422548
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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