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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorSimó Canonge, Rafael
dc.contributor.authorBogdanov Baruj, Patricia
dc.contributor.authorRamos Abellan, Hugo
dc.contributor.authorHuerta Alonso, Jordi
dc.contributor.authorSimó Servat, Olga
dc.contributor.authorHernández Pascual, Cristina
dc.date.accessioned2022-05-02T12:54:26Z
dc.date.available2022-05-02T12:54:26Z
dc.date.issued2021-08
dc.identifier.citationSimó R, Bogdanov P, Ramos H, Huerta J, Simó-Servat O, Hernández C. Effects of the topical administration of semaglutide on retinal neuroinflammation and vascular leakage in experimental diabetes. Biomedicines. 2021 Aug;9(8):926.
dc.identifier.issn2227-9059
dc.identifier.urihttp://hdl.handle.net/11351/7439
dc.descriptionDiabetic retinopathy; Retina; Semaglutide
dc.description.abstractBackground: An unexpected increase in the rate of severe diabetic retinopathy was observed in the Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN)-6 clinical trial. Although this effect was attributed to a rapid decrease in blood glucose levels, a direct deleterious effect of semaglutide on the retina could not be ruled out. In order to shed light on this issue, we have performed a study aimed at testing the direct effect of semaglutide administered by eye drops on retinal neuroinflammation and microvascular abnormalities using the db/db mouse model. Methods: Eye drops containing semaglutide (0.33 mg/mL; 5 μL once/daily) or vehicle (PBS; 5 μL once daily) were administered for 15 days. Results: We found that semaglutide significantly reduced glial activation, as well as the retinal expression of Nuclear factor kB (NF-κB), proinflammatory cytokines (IL-1β, IL-6, IL-18) and Intercellular Adhesion Molecule (ICAM)-1. In addition, semaglutide prevented the apoptosis of cells from the retinal ganglion layer and activated the protein kinase B (AKT) pathway. Finally, a dramatic decrease in vascular leakage was observed in db/db mice treated with semaglutide. All these findings were observed without any change in blood glucose levels and, therefore, can be directly attributed to semaglutide. Conclusions: These experimental findings point to a beneficial rather than a deleterious effect of semaglutide on the retina of subjects with diabetes.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesBiomedicines;9(8)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectDiabetis - Tractament
dc.subjectRetinopatia diabètica - Tractament
dc.subjectFarmacologia ocular
dc.subject.meshDiabetes Mellitus, Experimental
dc.subject.mesh/drug therapy
dc.subject.meshOphthalmic Solutions
dc.subject.meshInflammation
dc.titleEffects of the Topical Administration of Semaglutide on Retinal Neuroinflammation and Vascular Leakage in Experimental Diabetes
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/biomedicines9080926
dc.subject.decsdiabetes mellitus experimental
dc.subject.decs/farmacoterapia
dc.subject.decssoluciones oftálmicas
dc.subject.decsinflamación
dc.relation.publishversionhttps://doi.org/10.3390/biomedicines9080926
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Simó R, Bogdanov P, Ramos H, Simó-Servat O, Hernández C] Unitat de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. [Huerta J] Unitat de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid34440130
dc.identifier.wos000688854200001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F00541
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PI19%2F01215
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/SAF2016-77784-R
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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