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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBarber Caselles, Claudia
dc.contributor.authorMego Silva, Marianela
dc.contributor.authorSabater, Carlos
dc.contributor.authorVallejo, Fernando
dc.contributor.authorBendezú García, Rogger Alvaro
dc.contributor.authorMasihy Prieto, Marcela
dc.contributor.authorGuarner Aguilar, Francisco
dc.contributor.authorAzpiroz Vidaur, Fernando
dc.date.accessioned2022-05-02T13:03:46Z
dc.date.available2022-05-02T13:03:46Z
dc.date.issued2021-08
dc.identifier.citationBarber C, Mego M, Sabater C, Vallejo F, Bendezu RA, Masihy M, et al. Differential effects of western and mediterranean-type diets on gut microbiota: A metagenomics and metabolomics approach. Nutrients. 2021 Aug;13(8):2638.
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11351/7446
dc.descriptionMediterranean-type diet; Western-type diet; Intestinal gas
dc.description.abstractOur aim was to determine the effect of diet on gut microbiota, digestive function and sensations, using an integrated clinical, metagenomics and metabolomics approach. We conducted a cross-over, randomised study on the effects of a Western-type diet versus a fibre-enriched Mediterranean diet. In 20 healthy men, each diet was administered for 2 weeks preceded by a 2-week washout diet. The following outcomes were recorded: (a) number of anal gas evacuations; (b) digestive sensations; (c) volume of gas evacuated after a probe meal; (d) colonic content by magnetic resonance imaging; (e) gut microbiota taxonomy and metabolic functions by shotgun sequencing of faecal samples; (f) urinary metabolites using untargeted metabolomics. As compared to a Western diet, the Mediterranean diet was associated with (i) higher number of anal gas evacuations, (ii) sensation of flatulence and borborygmi, (iii) larger volume of gas after the meal and (iv) larger colonic content. Despite the relatively little difference in microbiota composition between both diets, microbial metabolism differed substantially, as shown by urinary metabolite profiles and the abundance of microbial metabolic pathways. The effects of the diet were less evident in individuals with robust microbiotas (higher beta-diversity). To conclude, healthy individuals tolerate dietary changes with minor microbial modifications at the composition level but with remarkable variation in microbial metabolism.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesNutrients;13(8)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectIntestins - Microbiologia
dc.subjectMetabolòmica
dc.subjectGenòmica
dc.subject.meshGastrointestinal Microbiome
dc.subject.meshMetagenomics
dc.subject.meshMetabolomics
dc.titleDifferential Effects of Western and Mediterranean-Type Diets on Gut Microbiota: A Metagenomics and Metabolomics Approach
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/nu13082638
dc.subject.decsmicrobiota intestinal
dc.subject.decsmetabolómica
dc.subject.decsmetagenómica
dc.relation.publishversionhttps://doi.org/10.3390/nu13082638
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Barber C, Mego M, Bendezu RA, Masihy M, Guarner F, Azpiroz F] Unitat de Recerca en l’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), 08035 Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sabater C] Department of Microbiology and Biochemistry, IPLA-CSIC, 33300 Asturias, Spain. Health Research Institute of Asturias, ISPA, 33011 Asturias, Spain. [Vallejo F] Metabolomics Service, CEBAS-CSIC, 30100 Murcia, Spain
dc.identifier.pmid34444797
dc.identifier.wos000690291800001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/SAF2016-76648-R
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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