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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorMa, Donghai
dc.contributor.authorCruz Carmona, Mª Jesús
dc.contributor.authorOjanguren Arranz, Iñigo
dc.contributor.authorRomero Mesones, Christian Eduardo
dc.contributor.authorVarona Porres, Diego
dc.contributor.authorMuñoz Gall, Fco. Javier
dc.date.accessioned2022-05-24T06:23:16Z
dc.date.available2022-05-24T06:23:16Z
dc.date.issued2021-11-24
dc.identifier.citationMa D, Cruz MJ, Ojanguren I, Romero-Mesones C, Varona-Porres D, Munoz X. Risk factors for the development of bronchiectasis in patients with asthma. Sci Rep. 2021 Nov 24;11:22820.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11351/7568
dc.descriptionAsthma; Medical research
dc.description.abstractThough asthma and bronchiectasis are two different diseases, their coexistence has been demonstrated in many patients. The aim of the present study is to compare the characteristics of asthmatic patients with and without bronchiectasis and to assess risk factors for the development of this condition. Two hundred and twenty-four moderate-severe asthmatic patients were included. The severity of bronchiectasis was assessed by Reiff and FACED parameters. Logistic regression was used to identify independent factors associated with bronchiectasis. Bronchiectasis was identified in 78 asthma patients. In severe asthma patients, its prevalence was 56.9%. Bronchiectasis was defined as mild in81% of patients using modified Reiff criteria and in 74% using FACED criteria. Asthmatic patients with bronchiectasis had decreasing FEV1, FVC and FEV1/FVC (p = 0.002, 0.005 and 0.014 respectively), presented more frequent asthma exacerbations (p < 0.001) and worse asthma control (ACT 21 vs 16pts, p < 0.001). Factors independently associated with bronchiectasis were older age (42–65 years: OR, 3.99; 95% CI 1.60 to 9.95, P = 0.003; ≥ 65 years: OR, 2.91; 95% CI 1.06 to 8.04, P = 0.039), severe asthma grade (OR, 8.91; 95% CI 3.69 to 21.49; P < 0.001) and frequency of asthma exacerbations (OR, 4.43; 95% CI 1.78 to 11.05; P < 0.001). In patients with severe asthma, age of asthma onset (OR, 1.02; 95% CI 1.01 to 1.04; P = 0.015) and asthma exacerbations (OR, 4.88; 95% CI 1.98 to 12.03; P = 0.001) were independently associated with the development of bronchiectasis. The prevalence of bronchiectasis in severe asthmatic patients is high. Age of asthma onset and exacerbations were independent factors associated with the occurrence of bronchiectasis.
dc.language.isoeng
dc.publisherNature Research
dc.relation.ispartofseriesScientific Reports;11
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectBronquièctasi - Factors de risc
dc.subjectAsma - Complicacions
dc.subject.meshBronchiectasis
dc.subject.mesh/diagnosis
dc.subject.meshAsthma
dc.subject.meshRisk Factors
dc.titleRisk factors for the development of bronchiectasis in patients with asthma
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41598-021-02332-w
dc.subject.decsbronquiectasia
dc.subject.decs/diagnóstico
dc.subject.decsasma
dc.subject.decsfactores de riesgo
dc.relation.publishversionhttps://doi.org/10.1038/s41598-021-02332-w
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Ma D, Romero-Mesones C] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Cruz MJ, Ojanguren I] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Varona-Porres D] Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Munoz X] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Departament de Fisiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid34819607
dc.identifier.wos000722365800084
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F01900
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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