Background Childhood Polyarteritis nodosa (PAN) is a systemic vasculitis with necrotizing inflammation of medium- and small-sized arteries. Disease evolution may be severe and refractory to standard treatment including prednisone, azathioprine and cyclophosphamide. Case presentation We present the case of a young girl with severe PAN resulting in progressive ischemia and necrosis of fingers and toes. Biological work-up revealed increased acute phase reactants and interleukin-6 levels. She was only partially controlled despite high-dose corticosteroids and cyclophosphamide infusions, and eventually achieved rapid improvement and sustained remission on tocilizumab. Further, we review the current evidence of the interleukin-6-inhibitor tocilizumab for the treatment of PAN. Conclusion Tocilizumab may be an efficient therapeutic option in a subset of treatment-refractory children with PAN.
Child; Polyarteritis nodosa; Tocilizumab
Boistault M, Lopez Corbeto M, Quartier P, Berbel Arcobé L, Carsi Durall A, Aeschlimann FA. A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report. Pediatr Rheumatol. 2021 Dec 3;19:168.
Use this identifier for quote and/or link this documenthttps://hdl.handle.net/11351/7572
This item appears in following collections
- HVH - Articles científics 
The following license files are associated with this item: