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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorLópez Sainz, Angela
dc.contributor.authorDentamaro, Ilaria
dc.contributor.authorGalián Gay, Laura
dc.contributor.authorCalvo Iglesias, Francisco
dc.contributor.authorAlegret, Josep M
dc.contributor.authorSanchez, Violeta
dc.contributor.authorSao Aviles, Augusto Cesar
dc.contributor.authorGutierrez García-Moreno, Laura
dc.contributor.authorTeixido Tura, Gisela
dc.contributor.authorEvangelista Masip, Artur
dc.contributor.authorRodríguez Palomares, Jose Fernando
dc.date.accessioned2022-05-31T08:42:49Z
dc.date.available2022-05-31T08:42:49Z
dc.date.issued2021-11-12
dc.identifier.citationLopez A, Dentamaro I, Galian L, Calvo F, Alegret JM, Sanchez V, et al. Predictors of Ascending Aorta Enlargement and Valvular Dysfunction Progression in Patients with Bicuspid Aortic Valve. J Clin Med. 2021 Nov 12;10(22):5264.
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/11351/7601
dc.descriptionAneurysm; Aortic stenosis; Bicuspid aortic valve
dc.description.abstractBicuspid aortic valve (BAV) patients are at high risk of developing progressive aortic valve dysfunction and ascending aorta dilation. However, the progression of the disease is not well defined. We aimed to assess mid-long-term aorta dilation and valve dysfunction progression and their predictors. Patients were referred from cardiac outpatient clinics to the echocardiographic laboratories of 10 tertiary hospitals and followed clinically and by echocardiography for >5 years. Seven hundred and eighteen patients with BAV (median age 47.8 years [IQR 33–62], 69.2% male) were recruited. BAV without raphe was observed in 11.3%. After a median follow-up of 7.2 years [IQR5–8], mean aortic root growth rate was 0.23 ± 0.15 mm/year. On multivariate analysis, rapid aortic root dilation (>0.35 mm/year) was associated with male sex, hypertension, presence of raphe and aortic regurgitation. Annual ascending aorta growth rate was 0.43 ± 0.32 mm/year. Rapid ascending aorta dilation was related only to hypertension. Variables associated with aortic stenosis and regurgitation progression, adjusted by follow-up time, were presence of raphe, hypertension and dyslipidemia and basal valvular dysfunction, respectively. Intrinsic BAV characteristics and cardiovascular risk factors were associated with aorta dilation and valvular dysfunction progression, taking into account the inherent limitations of our study-design. Strict and early control of cardiovascular risk factors is mandatory in BAV patients.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesJournal of Clinical Medicine;10(22)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCor - Vàlvules - Malalties - Complicacions
dc.subjectVasos sanguinis - Dilatació
dc.subjectInsuficiència aòrtica
dc.subject.meshHeart Valve Diseases
dc.subject.mesh/complications
dc.subject.meshAortic Valve Insufficiency
dc.subject.meshDilatation, Pathologic
dc.titlePredictors of Ascending Aorta Enlargement and Valvular Dysfunction Progression in Patients with Bicuspid Aortic Valve
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/jcm10225264
dc.subject.decsenfermedades de las válvulas cardíacas
dc.subject.decs/complicaciones
dc.subject.decsinsuficiencia de la válvula aórtica
dc.subject.decsdilatación patológica
dc.relation.publishversionhttps://doi.org/10.3390/jcm10225264
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Lopez A, Dentamaro I, Galian L, Sao-Aviles A, Gutiérrez L, Teixido-Tura G, Rodríguez-Palomares J] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Barcelona, Spain. [Calvo F] Cardiology Department, Hospital Alvaro Cunqueiro, Vigo, Spain. [Alegret JM] Cardiology Department, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain. [Sanchez V] Cardiology Department, University Hospital 12 de Octubre, Madrid, Spain. [Evangelista A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Barcelona, Spain. Heart Institute, Teknon Medical Center-Quirón Salud, Barcelona, Spain
dc.identifier.pmid34830546
dc.identifier.wos000725981700001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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