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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorGranziera, Cristina
dc.contributor.authorWuerfel, Jens
dc.contributor.authorBarkhof, Frederik
dc.contributor.authorCalabrese, Massimiliano
dc.contributor.authorDe Stefano, Nicola
dc.contributor.authorEnzinger, Christian
dc.contributor.authorRovira Cañellas, Alex
dc.date.accessioned2022-06-15T10:44:10Z
dc.date.available2022-06-15T10:44:10Z
dc.date.issued2021-05
dc.identifier.citationGranziera C, Wuerfel J, Barkhof F, Calabrese M, De Stefano N, Enzinger C, et al. Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis. Brain. 2021 May;144(5):1296–1311.
dc.identifier.issn1460-2156
dc.identifier.urihttp://hdl.handle.net/11351/7680
dc.descriptionImaging; Multiple sclerosis; Quantitative MRI
dc.description.abstractQuantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres. In patients with multiple sclerosis, quantitative MRI techniques such as relaxometry, myelin imaging, magnetization transfer, diffusion MRI, quantitative susceptibility mapping, and perfusion MRI, complement conventional MRI techniques by providing insight into disease mechanisms. These include: (i) presence and extent of diffuse damage in CNS tissue outside lesions (normal-appearing tissue); (ii) heterogeneity of damage and repair in focal lesions; and (iii) specific damage to CNS tissue components. This review summarizes recent technical advances in quantitative MRI, existing pathological validation of quantitative MRI techniques, and emerging applications of quantitative MRI to patients with multiple sclerosis in both research and clinical settings. The current level of clinical maturity of each quantitative MRI technique, especially regarding its integration into clinical routine, is discussed. We aim to provide a better understanding of how quantitative MRI may help clinical practice by improving stratification of patients with multiple sclerosis, and assessment of disease progression, and evaluation of treatment response.
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofseriesBrain;144(5)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectEsclerosi múltiple - Imatgeria per ressonància magnètica
dc.subjectImatgeria per al diagnòstic
dc.subject.meshMultiple Sclerosis
dc.subject.mesh/diagnostic imaging
dc.subject.meshNeuroimaging
dc.titleQuantitative magnetic resonance imaging towards clinical application in multiple sclerosis
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1093/brain/awab029
dc.subject.decsesclerosis múltiple
dc.subject.decs/diagnóstico por imagen
dc.subject.decsneuroimágenes
dc.relation.publishversionhttps://doi.org/10.1093/brain/awab029
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Granziera C] Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland. Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland. [Wuerfel J] Medical Image Analysis Center, Basel, Switzerland. Quantitative Biomedical Imaging Group (qbig), Department of Biomedical Engineering, University of Basel, Basel, Switzerland. [Barkhof F] Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, multiple sclerosis Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands. UCL Institutes of Healthcare Engineering and Neurology, London, UK. [Calabrese M] Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. [De Stefano N] Neurology, Department of Medicine, Surgery and Neuroscience, University of Siena, Italy. [Enzinger C] Department of Neurology and Division of Neuroradiology, Medical University of Graz, Graz, Austria. [Rovira À] Grup de Recerca en Neuroradiologia, Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid33970206
dc.identifier.wos000710927500019
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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