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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorOliva, Marc
dc.contributor.authorMulet Margalef, Núria
dc.contributor.authorOchoa de Olza, Maria
dc.contributor.authorNapoli, Stefania
dc.contributor.authorMas Lloret, Joan
dc.contributor.authorLaquente, Berta
dc.contributor.authorNuciforo, Paolo Giovanni
dc.date.accessioned2022-06-17T10:49:14Z
dc.date.available2022-06-17T10:49:14Z
dc.date.issued2021-02-01
dc.identifier.citationOliva M, Mulet-Margalef N, Ochoa-De-Olza M, Napoli S, Mas J, Laquente B, et al. Tumor-Associated Microbiome: Where Do We Stand? Int J Mol Sci. 2021 Feb 1;22(3):1446.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11351/7710
dc.descriptionDysbiosis; Gut microbiome; Tumor
dc.description.abstractThe study of the human microbiome in oncology is a growing and rapidly evolving field. In the past few years, there has been an exponential increase in the number of studies investigating associations of microbiome and cancer, from oncogenesis and cancer progression to resistance or sensitivity to specific anticancer therapies. The gut microbiome is now known to play a significant role in antitumor immune responses and in predicting the efficacy of immune-checkpoint inhibitors in cancer patients. Beyond the gut, the tumor-associated microbiome-microbe communities located either in the tumor or within its body compartment-seems to interact with the local microenvironment and the tumor immune contexture, ultimately impacting cancer progression and treatment outcome. However, pre-clinical research focusing on causality and mechanistic pathways as well as proof-of-concept studies are still needed to fully understand the potential clinical utility of microbiome in cancer patients. Moreover, there is a need for the standardization of methodology and the implementation of quality control across microbiome studies to allow for a better interpretation and greater comparability of the results reported between them. This review summarizes the accumulating evidence in the field and discusses the current and upcoming challenges of microbiome studies.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesInternational Journal of Molecular Sciences;22(3)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCàncer - Microbiologia
dc.subjectIntestins - Microbiologia
dc.subject.meshGastrointestinal Microbiome
dc.subject.meshTumor Microenvironment
dc.subject.meshNeoplasms
dc.subject.mesh/microbiology
dc.titleTumor-Associated Microbiome: Where Do We Stand?
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/ijms22031446
dc.subject.decsmicrobiota intestinal
dc.subject.decsmicroambiente tumoral
dc.subject.decsneoplasias
dc.subject.decs/microbiología
dc.relation.publishversionhttps://doi.org/10.3390/ijms22031446
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Oliva M, Mulet-Margalef N, Laquente B] Medical Oncology Department, Catalan Institute of Oncology L’Hospitalet de Llobregat, Catalonia, Spain. ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Catalonia, Spain. [Ochoa-De-Olza M] Service of Immuno-Oncology, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland. Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland. [Napoli S, Nuciforo P] Molecular Oncology Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Mas J] ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Catalonia, Spain. Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L’Hospitalet de Llobregat, Catalonia, Spain. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
dc.identifier.pmid33535583
dc.identifier.wos000615285000001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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