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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorMangas-Sánchez, Carmen
dc.contributor.authorGarriga-García, María
dc.contributor.authorSerrano-Nieto, María Juliana
dc.contributor.authorGarcía Romero, Ruth
dc.contributor.authorÁlvarez Beltrán, Marina
dc.contributor.authorCrehuá-Gaudiza, Elena
dc.date.accessioned2022-06-20T08:46:14Z
dc.date.available2022-06-20T08:46:14Z
dc.date.issued2021-12-09
dc.identifier.citationMangas-Sánchez C, Garriga-García M, Serrano-Nieto MJ, García-Romero R, Álvarez-Beltrán M, Crehuá-Gaudiza E, et al. Vitamin D Status in Pediatric and Young Adult Cystic Fibrosis Patients. Are the New Recommendations Effective? Nutrients. 2021 Dec 9;13(12):4413.
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11351/7721
dc.descriptionCystic fibrosis; Multicenter study; Vitamin D
dc.description.abstractIntroduction: In recent years, guidelines for vitamin D supplementation have been updated and prophylactic recommended doses have been increased in patients with cystic fibrosis (CF). Objective: To evaluate safety and efficacy of these new recommendations. Results: Two cohorts of pancreatic insufficient CF patients were compared before (cohort 1: 179 patients) and after (cohort 2: 71 patients) American CF Foundation and European CF Society recommendations were published. Cohort 2 patients received higher Vitamin D doses: 1509 (1306-1711 95% CI) vs 1084 (983-1184 95% CI) IU/Day (p < 0.001), had higher 25 OH vitamin D levels: 30.6 (27.9-33.26 95% CI) vs. 27.4 (25.9-28.8 95% CI) ng/mL (p = 0.028), and had a lower prevalence of insufficient vitamin D levels (<30 ng/mL): 48% vs 65% (p = 0.011). Adjusted by confounding factors, patients in cohort 1 had a higher risk of vitamin D insufficiency: OR 2.23 (1.09-4.57 95% CI) (p = 0.028). Conclusion: After the implementation of new guidelines, CF patients received higher doses of vitamin D and a risk of vitamin D insufficiency decreased. Despite this, almost a third of CF patients still do not reach sufficient serum calcidiol levels.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesNutrients;13(12)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectAvitaminosi D
dc.subjectFibrosi quística en infants
dc.subjectPosologia
dc.subject.meshVitamin D Deficiency
dc.subject.meshCystic Fibrosis
dc.subject.meshRecommended Dietary Allowances
dc.titleVitamin D Status in Pediatric and Young Adult Cystic Fibrosis Patients. Are the New Recommendations Effective?
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/nu13124413
dc.subject.decsdeficiencia de vitamina D
dc.subject.decsfibrosis quística
dc.subject.decscantidad dietética recomendada
dc.relation.publishversionhttps://doi.org/10.3390/nu13124413
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Mangas-Sánchez C] Pediatric Gastroenterology and Nutrition Section, Hospital Central de Asturias, Oviedo, Spain. [Garriga-García M] Cystic Fibrosis Section, Hospital Ramón y Cajal, Madrid, Spain. [Serrano-Nieto MJ] Pediatric Gastroenterology and Nutrition Section, Hospital Carlos Haya, Málaga, Spain. [García-Romero R] Pediatric Gastroenterology and Nutrition Section, Hospital Miguel Servet, Zaragoza, Spain. [Álvarez-Beltrán M] Secció de Nutrició i Gastroenterologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Crehuá-Gaudiza E] Pediatric Gastroenterology and Nutrition Section, Hospital Clínico de Valencia, Valencia, Spain
dc.identifier.pmid34959965
dc.identifier.wos000736882100001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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