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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorQuer Sivila, Josep
dc.contributor.authorColomer Castell, Sergi
dc.contributor.authorCampos Martinez, Carolina
dc.contributor.authorAndrés Verges, Cristina
dc.contributor.authorPiñana Moro, Maria
dc.contributor.authorCortese, Maria Francesca
dc.contributor.authorGonzález Sánchez, Alejandra
dc.contributor.authorGarcia Cehic, Damir
dc.contributor.authorIbañez Lligoña, Marta
dc.contributor.authorPumarola Suñé, Tomàs
dc.contributor.authorRodríguez Frias, Francisco
dc.contributor.authorAntón Pagarolas, Andres
dc.contributor.authorTabernero Caellas, David
dc.date.accessioned2022-08-12T06:31:18Z
dc.date.available2022-08-12T06:31:18Z
dc.date.issued2022-03-14
dc.identifier.citationQuer J, Colomer-Castell S, Campos C, Andrés C, Piñana M, Cortese MF, et al. Next-Generation Sequencing for Confronting Virus Pandemics. Viruses. 2022 Mar 14;14(3):600.
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/11351/7994
dc.descriptionCOVID-19; Pandemics; Viruses
dc.description.abstractVirus pandemics have happened, are happening and will happen again. In recent decades, the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of our global footprint and travel network, including the expansion of viral vectors and the destruction of natural spaces, bringing humans closer to wild animals. Once viral cross-species transmission to humans occurs, transmission cannot be stopped by cement walls but by developing barriers based on knowledge that can prevent or reduce the effects of any pandemic. Controlling a local transmission affecting few individuals is more efficient that confronting a community outbreak in which infections cannot be traced. Genetic detection, identification, and characterization of infectious agents using next-generation sequencing (NGS) has been proven to be a powerful tool allowing for the development of fast PCR-based molecular assays, the rapid development of vaccines based on mRNA and DNA, the identification of outbreaks, transmission dynamics and spill-over events, the detection of new variants and treatment of vaccine resistance mutations, the development of direct-acting antiviral drugs, the discovery of relevant minority variants to improve knowledge of the viral life cycle, strengths and weaknesses, the potential for becoming dominant to take appropriate preventive measures, and the discovery of new routes of viral transmission.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesViruses;14(3)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectMedicaments antivírics
dc.subjectSeqüència de nucleòtids
dc.subjectEpidèmies
dc.subject.meshPandemics
dc.subject.meshHigh-Throughput Nucleotide Sequencing
dc.subject.meshAntiviral Agents
dc.titleNext-Generation Sequencing for Confronting Virus Pandemics
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/v14030600
dc.subject.decspandemias
dc.subject.decssecuenciación de nucleótidos de alto rendimiento
dc.subject.decsantivíricos
dc.relation.publishversionhttps://doi.org/10.3390/v14030600
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Quer J] Grup de Recerca en Malalties Hepàtiques, Unitat del Fetge, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Colomer-Castell S, Campos C, Garcia-Cehic D] Grup de Recerca en Malalties Hepàtiques, Unitat del Fetge, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. [Andrés C, Piñana M, González-Sánchez A] Servei de Microbiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Cortese MF] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. Grup de Recerca en Bioquímica Clínica, Servei de Bioquímica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Ibáñez M] Grup de Recerca en Malalties Hepàtiques, Unitat del Fetge, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Pumarola T, Antón A] Servei de Microbiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rodríguez-Frías F] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Recerca en Bioquímica Clínica, Servei de Bioquímica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Tabernero D] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid35337007
dc.identifier.wos000774535100001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PI19%2F00301
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0016%2F0003
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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