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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorAliberti, Stefano
dc.contributor.authorAmati, Francesco
dc.contributor.authorGramegna, Andrea
dc.contributor.authorVigone, Barbara
dc.contributor.authorOriano, Martina
dc.contributor.authorSotgiu, Giovanni
dc.contributor.authorPolverino, Eva
dc.date.accessioned2022-08-16T06:52:57Z
dc.date.available2022-08-16T06:52:57Z
dc.date.issued2022-01
dc.identifier.citationAliberti S, Amati F, Gramegna A, Vigone B, Oriano M, Sotgiu G, et al. Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients. ERJ Open Res. 2022 Jan;8(1):00388–2021.
dc.identifier.issn2312-0541
dc.identifier.urihttp://hdl.handle.net/11351/8004
dc.descriptionImmunological tests; Bronchiectasis
dc.description.abstractBackground The reported prevalence of immunodeficiencies in bronchiectasis patients is variable depending on the frequency and extent of immunological tests performed. European Respiratory Society guidelines recommend a minimum bundle of tests. Broadening the spectrum of immunological tests could increase the number of patients diagnosed with an immunodeficiency and those who could receive specific therapy. The primary objective of the present study was to assess the performance of different sets of immunological tests in diagnosing any, primary, secondary or treatable immunodeficiencies in adults with bronchiectasis. Methods An observational, cross-sectional study was conducted at the Bronchiectasis Program of the Policlinico University Hospital in Milan, Italy, from September 2016 to June 2019. Adult outpatients with a clinical and radiological diagnosis of bronchiectasis underwent the same immunological screening during the first visit when clinically stable consisting of: complete blood count; immunoglobulin (Ig) subclass tests for IgA, IgG, IgM and IgG; total IgE; lymphocyte subsets; and HIV antibodies. The primary endpoint was the prevalence of patients with any immunodeficiencies using five different sets of immunological tests. Results A total of 401 bronchiectasis patients underwent the immunological screening. A significantly different prevalence of bronchiectasis patients diagnosed with any, primary or secondary immunodeficiencies was found across different bundles. 44.6% of bronchiectasis patients had a diagnosis of immunodeficiency when IgG subclasses and lymphocyte subsets were added to the minimum bundle suggested by the guidelines. Conclusion A four-fold increase in the diagnosis of immunodeficiencies can be found in adults with bronchiectasis when IgG subclasses and lymphocyte subsets are added to the bundle of tests recommended by guidelines.
dc.language.isoeng
dc.publisherEuropean Respiratory Society
dc.relation.ispartofseriesERJ Open Research;8(1)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectBronquièctasi
dc.subjectImmunodeficiència
dc.subject.meshBronchiectasis
dc.subject.meshCommon Variable Immunodeficiency
dc.subject.mesh/diagnosis
dc.titleComparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1183/23120541.00388-2021
dc.subject.decsbronquiectasia
dc.subject.decsinmunodeficiencia variable común
dc.subject.decs/diagnóstico
dc.relation.publishversionhttp://dx.doi.org/10.1183/23120541.00388-2021
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Aliberti S, Amati F] Dept of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. IRCCS Humanitas Research Hospital, Respiratory Unit, Rozzano, Italy. [Gramegna A, Oriano M] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy. Dept of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. [Vigone B] Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. [Sotgiu G] Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. [Polverino E] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
dc.identifier.pmid35350277
dc.identifier.wos000783165900012
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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