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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorMorfouace, Marie
dc.contributor.authorNovello, S.
dc.contributor.authorStevovic, A.
dc.contributor.authorDooms, C.
dc.contributor.authorJanzic, Urska
dc.contributor.authorBerghmans, Thierry
dc.contributor.authorFelip Font, Enriqueta
dc.date.accessioned2022-09-06T12:32:13Z
dc.date.available2022-09-06T12:32:13Z
dc.date.issued2022-05-18
dc.identifier.citationMorfouace M, Novello S, Stevovic A, Dooms C, Janžič U, Berghmans T, et al. Results of screening in early and advanced thoracic malignancies in the EORTC pan-European SPECTAlung platform. Sci Rep. 2022 May 18;12:8342.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11351/8038
dc.descriptionCancer screening; Non-small-cell lung cancer
dc.description.abstractAccess to a comprehensive molecular alteration screening is patchy in Europe and quality of the molecular analysis varies. SPECTAlung was created in 2015 as a pan-European screening platform for patients with thoracic malignancies. Here we report the results of almost 4 years of prospective molecular screening of patients with thoracic malignancies, in terms of quality of the program and molecular alterations identified. Patients with thoracic malignancies at any stage of disease were recruited in SPECTAlung, from June 2015 to May 2019, in 7 different countries. Molecular tumour boards were organised monthly to discuss patients’ molecular and clinical profile and possible biomarker-driven treatments, including clinical trial options. FFPE material was collected and analysed for 576 patients with diagnosis of pleural, lung, or thymic malignancies. Ultimately, 539 patients were eligible (93.6%) and 528 patients were assessable (91.7%). The turn-around time for report generation and molecular tumour board was 214 days (median). Targetable molecular alterations were observed in almost 20% of cases, but treatment adaptation was low (3% of patients). SPECTAlung showed the feasibility of a pan-European screening platform. One fifth of the patients had a targetable molecular alteration. Some operational issues were discovered and adapted to improve efficiency.
dc.language.isoeng
dc.publisherNature Portfolio
dc.relation.ispartofseriesScientific Reports;12
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectTòrax - Càncer - Diagnòstic
dc.subjectDiagnòstic molecular
dc.subjectCribatge (Medicina)
dc.subject.meshThoracic Neoplasms
dc.subject.mesh/diagnosis
dc.subject.meshMolecular Diagnostic Techniques
dc.subject.meshDiagnostic Screening Programs
dc.titleResults of screening in early and advanced thoracic malignancies in the EORTC pan-European SPECTAlung platform
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41598-022-12056-0
dc.subject.decsneoplasias torácicas
dc.subject.decs/diagnóstico
dc.subject.decstécnicas de diagnóstico molecular
dc.subject.decsprogramas de cribado diagnóstico
dc.relation.publishversionhttps://doi.org/10.1038/s41598-022-12056-0
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Morfouace M, Stevovic A] EORTC HQ, 1200 Brussels, Belgium. [Novello S] Department of Oncology, University of Turin, AOU San Luigi, Orbassano (TO), Italy. [Dooms C] Department of Respiratory Diseases and Respiratory Oncology Unit, University Hospitals KU Leuven, Leuven, Belgium. [Janžič U] Department of Medical Oncology, University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia. [Berghmans T] Thoracic Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. [Felip E] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.identifier.pmid35585228
dc.identifier.wos000797636300010
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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