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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBradbury Lobato, Melissa
dc.contributor.authorBorras, Eva
dc.contributor.authorCastellví Vives, Josep
dc.contributor.authorMendez Fernández, Olga
dc.contributor.authorSánchez Iglesias, José Luis
dc.contributor.authorPerez Benavente, Maria Asuncion
dc.contributor.authorGil Moreno, Antonio
dc.contributor.authorSabidó, Eduard
dc.contributor.authorSantamaria Margalef, Anna
dc.date.accessioned2022-09-07T11:29:36Z
dc.date.available2022-09-07T11:29:36Z
dc.date.issued2022-03-15
dc.identifier.citationBradbury M, Borràs E, Castellví J, Méndez O, Sánchez-Iglesias JL, Pérez-Benavente A, et al. BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling. Sci Rep. 2022 Mar 15;12:4445.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11351/8045
dc.descriptionOvarian cancer; Proteomics
dc.description.abstractDespite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis with the addition of valuable ubiquitination profiling, and their dependency on BRCA1 mutation-state directly in patient-derived tissues. Using a multilayered proteomic approach, we show the tight coordination between the ubiquitination and phosphorylation regulatory layers and their role in key cellular processes related to BRCA1-dependent HGSC pathogenesis. In addition, we identify key bridging proteins, kinase activity, and post-translational modifications responsible for molding distinct cancer phenotypes, thus providing new opportunities for therapeutic intervention, and ultimately advance towards a more personalized patient care.
dc.language.isoeng
dc.publisherNature Portfolio
dc.relation.ispartofseriesScientific Reports;12
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectOvaris - Càncer
dc.subjectMutació (Biologia)
dc.subjectADN - Reparació
dc.subject.meshOvarian Neoplasms
dc.subject.meshMutation
dc.subject.meshDNA Repair
dc.titleBRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41598-022-08461-0
dc.subject.decsneoplasias ováricas
dc.subject.decsmutación
dc.subject.decsreparación del ADN
dc.relation.publishversionhttps://doi.org/10.1038/s41598-022-08461-0
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Bradbury M] Proteomics Unit, Centre de Regulació Genòmica, Barcelona Institute of Science and Technology (BIST), 08003 Barcelona, Spain. Universitat Pompeu Fabra, 08003 Barcelona, Spain. Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Borràs E, Sabidó E] Proteomics Unit, Centre de Regulació Genòmica, Barcelona Institute of Science and Technology (BIST), 08003 Barcelona, Spain. Universitat Pompeu Fabra, 08003 Barcelona, Spain. [Castellví J] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Méndez O] Laboratori de Cicle Cel•lular i Càncer, Grup de Recerca Biomèdica en Urologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sánchez-Iglesias JL, Pérez-Benavente A] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Gil-Moreno A] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain. [Santamaria A] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Laboratori de Cicle Cel•lular i Càncer, Grup de Recerca Biomèdica en Urologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid35292711
dc.identifier.wos000769466200020
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/823839
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F01017
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PI21%2F00977
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CP13%2F00158
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CPII18%2F00027
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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