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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorAstorga Gamaza, Antonio
dc.contributor.authorGrau Exposito, Judit
dc.contributor.authorBurgos Cibrian, Joaquin
dc.contributor.authorNavarro Mercadé, Jordi
dc.contributor.authorCurran Fàbregas, Adria
dc.contributor.authorPlanas Ribas, Bibiana
dc.contributor.authorSuanzes Diez, Paula
dc.contributor.authorFalcó Ferrer, Vicenç
dc.contributor.authorGenesca Ferrer, Meritxell
dc.contributor.authorBuzón Gómez, María José
dc.date.accessioned2022-09-07T12:24:34Z
dc.date.available2022-09-07T12:24:34Z
dc.date.issued2022-05-26
dc.identifier.citationAstorga-Gamaza A, Grau-Expósito J, Burgos J, Navarro J, Curran A, Planas B, et al. Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response. Elife. 2022 May 26;11:e78294.
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/11351/8060
dc.descriptionHIV; Infectious disease; Reservoir
dc.description.abstractHuman immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous cell reservoirs, which can be maintained by different mechanisms including cellular proliferation, and represent the main obstacle to curing the infection. The expression of the Fcγ receptor CD32 has been identified as a marker of the active cell reservoirs in people on antiretroviral therapy (ART), but if its expression has any role in conferring advantage for viral persistence is unknown. Here, we report that HIV-infected cells expressing CD32 have reduced susceptibility to natural killer (NK) antibody-dependent cell cytotoxicity (ADCC) by a mechanism compatible with the suboptimal binding of HIV-specific antibodies. Infected CD32 cells have increased proliferative capacity in the presence of immune complexes, and are more resistant to strategies directed to potentiate NK function. Remarkably, reactivation of the latent reservoir from antiretroviral-treated people living with HIV increases the pool of infected CD32 cells, which are largely resistant to the ADCC immune mechanism. Thus, we report the existence of reservoir cells that evade part of the NK immune response through the expression of CD32.
dc.language.isoeng
dc.publishereLife Sciences Publications
dc.relation.ispartofserieseLife;11
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectInfeccions per VIH
dc.subjectImmunoglobulines
dc.subjectImmunitat
dc.subject.meshHIV Infections
dc.subject.meshHIV Antibodies
dc.subject.meshImmunity
dc.titleIdentification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.7554/eLife.78294
dc.subject.decsinfecciones por VIH
dc.subject.decsanticuerpos VIH
dc.subject.decsinmunidad
dc.relation.publishversionhttps://doi.org/10.7554/eLife.78294
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliationServei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid35616530
dc.identifier.wos000808497200001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RTI2018-101082-B-I00
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI17%2F01470
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0025%2F0007
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CP17%2F00179
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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