Show simple item record

 
dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBolufer Cardona, Monica
dc.contributor.authorGarcía-Carro, Clara
dc.contributor.authorBlasco, Miquel
dc.contributor.authorQuintana, Luis F
dc.contributor.authorShabaka, Amir
dc.contributor.authorRabasco, Cristina
dc.date.accessioned2022-09-07T12:26:43Z
dc.date.available2022-09-07T12:26:43Z
dc.date.issued2022-05
dc.identifier.citationBolufer M, García-Carro C, Blasco M, Quintana LF, Shabaka A, Rabasco C, et al. Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study. J Clin Med. 2022 May;11(10):2915.
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/11351/8061
dc.descriptionKidney biopsy; Renal pathology; Solid organ neoplasm
dc.description.abstractBackground: Currently, following the new advances in cancer treatments and the increasing prevalence of kidney disease in the population, more kidney biopsies are being performed. The aim of our study is to analyze clinical and histological characteristics of patients with active solid organ malignancy who underwent kidney biopsy. This is a multi-center collaborative retrospective study supported by groups GLOSEN/Onconephrology from the Spanish Society of Nephrology. Clinical, demographical and histological data were collected. Results: A total of 148 patients with cancer who underwent a kidney biopsy from 12 hospitals were included. 64.3% men and mean age of 66.9 years old. The indications for biopsy were acute renal injury (67.1%), proteinuria (17.1%), exacerbated chronic kidney disease (8.2%), and chronic kidney disease (7.5%). Most frequent malignances were lung (29.1%) and abdominal (25%), with 49.7% metastatic cancer. As oncospecific treatment, 28% received chemotherapy, 29.3% immunotherapy, 19.3% specific therapies, and 2.1% conservative treatment. At the time of kidney biopsy, median creatinine was of 2.58 mg/dL [1.81–4.1 (IQ 25–75)], median urine protein-to-creatinine ratio of 700 mg/g [256–2463 (IQ 25–75)] and 53.1% presented hematuria. The most frequent renal biopsy diagnoses were: acute interstitial nephritis (39.9%), acute tubular necrosis (8.8%), IgA nephropathy (7.4%) and membranous nephropathy (6.1%). Median follow-up was 15.2 months [5.7–31.4 (IQ 25–75)]. Conclusions: There is a new trend in kidney disease and cancer patients in terms of diagnosis and treatment. Acute interstitial nephritis has established itself as the most common kidney injury in patients with cancer who underwent a kidney biopsy. Renal biopsy is a valuable tool for diagnosis, treatment, and prognosis of solid organ cancer patients with kidney damage.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesJournal of Clinical Medicine;11(10)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCàncer - Tractament
dc.subjectRonyons - Biòpsia
dc.subjectRonyons - Malalties
dc.subject.meshBiopsy
dc.subject.meshAcute Kidney Injury
dc.subject.mesh/diagnosis
dc.subject.meshNeoplasms
dc.titleKidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/jcm11102915
dc.subject.decsbiopsia
dc.subject.decslesión renal aguda
dc.subject.decs/diagnóstico
dc.subject.decsneoplasias
dc.relation.publishversionhttps://doi.org/10.3390/jcm11102915
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Bolufer M] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CSUR National Unit of Expertise for Complex Glomerular Diseases of Spain, 08035 Barcelona, Spain. [García-Carro C] Nephrology Department, San Carlos Clinical University Hospital, 28034 Madrid, Spain. [Blasco M, Quintana LF] Department of Nephrology and Renal Transplantation, Hospital Clínic, IDIBAPS, CSUR National Unit of Expertise for Complex Glomerular Diseases of Spain, 08035 Barcelona, Spain. [Shabaka A] Nephrology Department, Fundación Alcorcón, 28922 Alcorcón, Spain. [Rabasco C] Nephrology Department, Córdoba Hospital, 14071 Córdoba, Spain
dc.identifier.pmid35629041
dc.identifier.wos000802409700001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/CM20%2F00111
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PI21%2F01292
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0009%2F0030
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/RD21%2F0005%2F0016
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record