Show simple item record

 
dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorSalvo Romero, Eloisa
dc.contributor.authorRodiño Janeiro, Bruno Kotska
dc.contributor.authorAlbert Bayo, Merce
dc.contributor.authorLobo Alvarez, Beatriz
dc.contributor.authorSantos Vicente, Fco Javier
dc.contributor.authorFarre, Ricard
dc.contributor.authorMartínez, Cristina
dc.contributor.authorVicario Perez, Maria
dc.date.accessioned2022-09-07T12:30:38Z
dc.date.available2022-09-07T12:30:38Z
dc.date.issued2022-05
dc.identifier.citationSalvo-Romero E, Rodiño-Janeiro BK, Albert-Bayo M, Lobo B, Santos J, Farré R, et al. Eosinophils in the Gastrointestinal Tract: Key Contributors to Neuro-Immune Crosstalk and Potential Implications in Disorders of Brain-Gut Interaction. Cells. 2022 May;11(10):1644.
dc.identifier.issn2073-4409
dc.identifier.urihttp://hdl.handle.net/11351/8062
dc.descriptionDisorders of brain-gut interaction; Intestinal eosinophils; Neuro-immune interaction
dc.description.abstractEosinophils are innate immune granulocytes actively involved in defensive responses and in local and systemic inflammatory processes. Beyond these effector roles, eosinophils are fundamental to maintaining homeostasis in the tissues they reside. Gastrointestinal eosinophils modulate barrier function and mucosal immunity and promote tissue development through their direct communication with almost every cellular component. This is possible thanks to the variety of receptors they express and the bioactive molecules they store and release, including cytotoxic proteins, cytokines, growth factors, and neuropeptides and neurotrophines. A growing body of evidence points to the eosinophil as a key neuro-immune player in the regulation of gastrointestinal function, with potential implications in pathophysiological processes. Eosinophil–neuron interactions are facilitated by chemotaxis and adhesion molecules, and the mediators released may have excitatory or inhibitory effects on each cell type, with physiological consequences dependent on the type of innervation involved. Of special interest are the disorders of the brain–gut interaction (DBGIs), mainly functional dyspepsia (FD) and irritable bowel syndrome (IBS), in which mucosal eosinophilia and eosinophil activation have been identified. In this review, we summarize the main roles of gastrointestinal eosinophils in supporting gut homeostasis and the evidence available on eosinophil–neuron interactions to bring new insights that support the fundamental role of this neuro-immune crosstalk in maintaining gut health and contributing to the pathophysiology of DBGIs.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesCells;11(10)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectAparell digestiu - Malalties
dc.subjectHomeòstasi
dc.subjectEosinòfils
dc.subject.meshEosinophils
dc.subject.meshHomeostasis
dc.subject.meshGastrointestinal Diseases
dc.titleEosinophils in the Gastrointestinal Tract: Key Contributors to Neuro-Immune Crosstalk and Potential Implications in Disorders of Brain-Gut Interaction
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/cells11101644
dc.subject.decseosinófilos
dc.subject.decshomeostasis
dc.subject.decsenfermedades gastrointestinales
dc.relation.publishversionhttps://doi.org/10.3390/cells11101644
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Salvo-Romero E] Grup de Recerca Translacional d'Immunologia de la Mucosa, Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Laboratori de Neuroimmuno-Gastroenterologia, Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rodiño-Janeiro BK] Laboratori de Neuroimmuno-Gastroenterologia, Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Albert-Bayo M] Grup de Recerca Translacional d'Immunologia de la Mucosa, Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Lobo B] Laboratori de Neuroimmuno-Gastroenterologia, Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Gastroenterologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Santos J] Laboratori de Neuroimmuno-Gastroenterologia, Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Gastroenterologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Farré R] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029 Madrid, Spain. Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 3000 Leuven, Belgium. [Martinez C] Vascular and Renal Translational Research Group, Lleida Institute for Biomedical Research Dr. Pifarré Foundation (IRBLleida), 25198 Lleida, Spain. [Vicario M] Grup de Recerca Translacional d'Immunologia de la Mucosa, Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029 Madrid, Spain. Department of Gastrointestinal Health, Nestlé Institute of Health Sciences, Société des Produits Nestlé S.A., Nestlé Research, Vers-chez-les-Blanc, 1000 Lausanne, Switzerland
dc.identifier.pmid35626681
dc.identifier.wos000803579700001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CD15/2F00010
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/FI20%2F00256
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PI19%2F01643
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CPII16%2F00031
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PI19%2F01643
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record