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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorSantos García, Diego
dc.contributor.authorde Deus Fonticoba, Teresa
dc.contributor.authorCores Bartolomé, Carlos
dc.contributor.authorFeal Painceiras, María
dc.contributor.authorSuárez Castro, Ester
dc.contributor.authorCanfield, Hector
dc.contributor.authorHernández Vara, Jorge
dc.contributor.authorde Fabregues-Boixar Nebot, Oriol
dc.date.accessioned2022-09-09T09:46:13Z
dc.date.available2022-09-09T09:46:13Z
dc.date.issued2022-05-05
dc.identifier.citationSantos-García D, de Deus Fonticoba T, Bartolomé CC, Painceiras MJF, Castro ES, Canfield H, et al. Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study. Diagnostics. 2022 May 5;12(5):1147.
dc.identifier.issn2075-4418
dc.identifier.urihttp://hdl.handle.net/11351/8106
dc.descriptionParkinson’s disease; Motor fluctuations; Non-motor symptoms
dc.description.abstractThe aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score ≥ 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 ± 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 ± 36.48 vs. 34.3 ± 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 ± 37.37) compared to those who did not develop MF (+6.2 ± 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (β = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesDiagnostics;12(5)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectParkinson, Malaltia de - Prognosi
dc.subject.meshParkinson Disease
dc.subject.meshDisease Progression
dc.titleMotor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/diagnostics12051147
dc.subject.decsenfermedad de Parkinson
dc.subject.decsprogresión de la enfermedad
dc.relation.publishversionhttps://doi.org/10.3390/diagnostics12051147
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Santos-García D, Bartolomé CC, Painceiras MJF] Department of Neurology, Hospital Universitario de A Coruña (HUAC), Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain. [de Deus Fonticoba T, Suárez Castro E, Canfield H] CHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain. [Hernández-Vara J] CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Madrid, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [de Fábregues O] Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid35626303
dc.identifier.wos000804280200001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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