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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorEraso, Arantxa
dc.contributor.authorSanz, Javier
dc.contributor.authorMolla, Meritxell
dc.contributor.authorReyes López, Victoria
dc.contributor.authorPedro, Agustí
dc.contributor.authorArenas, Meritxell
dc.date.accessioned2022-09-09T12:18:19Z
dc.date.available2022-09-09T12:18:19Z
dc.date.issued2022-08
dc.identifier.citationEraso A, Sanz J, Mollà M, Reyes V, Pedro A, Arenas M, et al. Evidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group. Clin Transl Oncol. 2022 Aug;24:1580–7.
dc.identifier.issn1699-3055
dc.identifier.urihttp://hdl.handle.net/11351/8111
dc.descriptionBreast cancer; Hypofractionation; Radiotherapy
dc.description.abstractIntroduction Daily, moderate hypofractionation has become standard treatment for breast cancer following breast-conserving surgery, although substantial variation exists in its use. This paper describes the generation of consensus-based recommendations for the utilisation of this therapy at the healthcare system level and compares these to American Society for Radiation Oncology (ASTRO) guidelines. Materials and methods Consensus-based guidelines were developed in three steps, including a systematic literature review and involvement of radiation oncologists specialising in breast cancer in Catalonia: (a) creation of a working group and evidence review; (b) consideration of the levels of evidence and agreement on the formulation of survey questions; and (c) performance of survey and development of consensus-based recommendations. Results were compared to the ASTRO recommendations. Results Consensus was above 80% for 10 of the 14 survey items. Experts supported hypofractionated radiotherapy for all breast cancer patients aged 40 years or more; with invasive carcinoma and breast-conserving surgery; without radiation of lymph nodes; and regardless of the tumour size, histological grade, molecular subtype, breast size, laterality, other treatment characteristics, or need for a boost. Over half favoured its use in all situations, even where available scientific evidence is insufficient. The resulting recommendations and the quality of the evidence are comparable to those from ASTRO, despite some differences in the degree of consensus. Conclusion Specialists agree that hypofractionation is the standard treatment for breast cancer following breast-conserving surgery, but some specific areas require a higher level of evidence before unequivocally extending indications.
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesClinical and Translational Oncology;24
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectRadiació - Dosificació
dc.subjectMastectomia
dc.subjectMama - Càncer - Radioteràpia
dc.subject.meshRadiation Dose Hypofractionation
dc.subject.meshMastectomy, Segmental
dc.subject.meshBreast Neoplasms
dc.subject.mesh/radiotherapy
dc.titleEvidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1007/s12094-022-02798-8
dc.subject.decshipofraccionamiento de la dosis de radiación
dc.subject.decsmastectomía segmentaria
dc.subject.decsneoplasias de la mama
dc.subject.decs/radioterapia
dc.relation.publishversionhttps://doi.org/10.1007/s12094-022-02798-8
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Eraso A] Radiation Oncology Department, Institut Català d’Oncologia Girona, Girona, Spain. [Sanz J] Radiation Oncology Department, Hospital del Mar, Barcelona, Spain. [Mollà M] Radiation Oncology Department, Hospital Clínic de Barcelona, Barcelona, Spain. [Reyes V] Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Pedro A] Radiation Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Arenas M] Radiation Oncology Department, Hospital Universitari Sant Joan de Reus, Reus, Spain
dc.identifier.pmid35190961
dc.identifier.wos000758962600001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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